{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:35:16Z","timestamp":1760888116440},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,7,17]],"date-time":"2007-07-17T00:00:00Z","timestamp":1184630400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Periodontitis is a multifactorial disease and immunologic and genetic factors have an important role in its pathogenesis. Mutation in the promoter regions of the interleukin\u20104 and interferon\u2010\u03b3 genes has been reported to modify the protein expression. The objective of this study was to evaluate the possible role of interleukin\u20104 (C\u2010590T) and interferon\u2010\u03b3 (G5644A) polymorphisms in the susceptibility to periodontitis.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> In this case\u2013control study, 53 patients (36 women and 17 men), comprising 27 patients with aggressive periodontitis and 26 patients with chronic periodontitis, and 56 healthy volunteers, were enrolled. DNA was isolated from all subjects, and the polymerase chain reaction\u2010sequence specific primer method was used to study the interleukin\u20104 (C\u2010590T) and interferon\u2010\u03b3 (G5644A) gene polymorphisms.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Our results showed no significant difference in the allele and genotype frequencies of interleukin\u20104 (C\u2010590T) and interferon\u2010\u03b3 (G5644A) gene polymorphisms between patients with periodontal disease and controls.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The results suggest that the interleukin\u20104 (C\u2010590T) and interferon\u2010\u03b3 (G5644A) gene polymorphisms may not be associated with the susceptibility of Iranian individuals to periodontitis.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2007.01006.x","type":"journal-article","created":{"date-parts":[[2007,7,18]],"date-time":"2007-07-18T03:45:58Z","timestamp":1184730358000},"page":"111-115","source":"Crossref","is-referenced-by-count":14,"title":["Interleukin\u20104 (C\u2010590T) and interferon\u2010\u03b3 (G5644A) gene polymorphisms in patients with periodontitis"],"prefix":"10.1111","volume":"43","author":[{"given":"B.","family":"Hooshmand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hajilooi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Rafiei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KH","family":"Mani\u2010Kashani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ghasemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,9,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00190.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(00)00391-9"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.5.2125-2130.1999"},{"key":"e_1_2_5_5_2","first-page":"147","article-title":"Two types of murine helper T cell clones. 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