{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:35:15Z","timestamp":1760888115558},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,8,24]],"date-time":"2007-08-24T00:00:00Z","timestamp":1187913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Our previous study showed that topical alendronate, an inhibitor of bone resorption, reduces root resorption and ankylosis for 21\u2003d after replantation of rat teeth. The aim of the present study was to evaluate the long\u2010term inhibitory effects of topical alendronate in the replanted teeth.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> The rat maxillary first molars were extracted, placed in saline containing 1\u2003m<jats:sc>m<\/jats:sc> alendronate (alendronate group) or saline (saline group) for 5\u2003min and then replanted. The maxillae were dissected at 60 and 120\u2003d. Microcomputed tomography horizontal sections at three root levels were analyzed for root and bone resorption, ankylosis and pulp mineralization.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In the alendronate group at 60 and 120\u2003d, the frequencies of resorption of roots and bone were lower than those in the saline group. The <jats:italic>p<\/jats:italic> values show statistical significances of lower frequencies in the alendronate group than in the saline group by chi\u2010square test (see <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#t1\">Table\u00a01<\/jats:ext-link>). Ankylosis and pulp mineralization occurred in the alendronate and saline groups. Bone marrow spaces were narrowed in conjunction with bone tissue expansion around the replanted teeth in the alendronate group.<\/jats:p><jats:p><jats:table-wrap>\n\n<jats:caption><jats:title>\u2002Percentage of sites with ankylosis, root resorption, bone resorption and pulp mineralization for the alendronate and saline groups at 60 and 120\u2003d after tooth replantation<\/jats:title><\/jats:caption>\n\n<jats:table frame=\"hsides\">\n<jats:col \/>\n<jats:col \/>\n<jats:col \/>\n<jats:col \/>\n<jats:col \/>\n<jats:col \/>\n<jats:thead>\n<jats:tr>\n<jats:th>Days<\/jats:th>\n<jats:th>Group<\/jats:th>\n<jats:th>Ankylosis<\/jats:th>\n<jats:th>Root resorption<\/jats:th>\n<jats:th>Bone resorption<\/jats:th>\n<jats:th>Pulp mineralization<\/jats:th>\n<\/jats:tr>\n<\/jats:thead>\n<jats:tbody>\n<jats:tr>\n<jats:td>\u200260<\/jats:td>\n<jats:td>Alendronate<\/jats:td>\n<jats:td>28<\/jats:td>\n<jats:td>3.5<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#t1n3\">***<\/jats:ext-link><\/jats:td>\n<jats:td>16<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#t1n5\">*<\/jats:ext-link><\/jats:td>\n<jats:td>81<\/jats:td>\n<\/jats:tr>\n<jats:tr>\n<jats:td>(80\/288)<\/jats:td>\n<jats:td>(10\/288)<\/jats:td>\n<jats:td>(47\/288)<\/jats:td>\n<jats:td>(58\/72)<\/jats:td>\n<\/jats:tr>\n<jats:tr>\n<jats:td>\u200260<\/jats:td>\n<jats:td>Saline<\/jats:td>\n<jats:td>35<\/jats:td>\n<jats:td>27<\/jats:td>\n<jats:td>25<\/jats:td>\n<jats:td>89<\/jats:td>\n<\/jats:tr>\n<jats:tr>\n<jats:td>(51\/144<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#t1n1\"><jats:sup>a<\/jats:sup><\/jats:ext-link>)<\/jats:td>\n<jats:td>(51\/192)<\/jats:td>\n<jats:td>(48\/192)<\/jats:td>\n<jats:td>(32\/36<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#t1n1\"><jats:sup>a<\/jats:sup><\/jats:ext-link>)<\/jats:td>\n<\/jats:tr>\n<jats:tr>\n<jats:td>120<\/jats:td>\n<jats:td>Alendronate<\/jats:td>\n<jats:td>46<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#t1n2\">###<\/jats:ext-link><\/jats:td>\n<jats:td>3.3<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#t1n3\">***<\/jats:ext-link><\/jats:td>\n<jats:td>22<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#t1n4\">**<\/jats:ext-link><\/jats:td>\n<jats:td>70<\/jats:td>\n<\/jats:tr>\n<jats:tr>\n<jats:td>(155\/336)<\/jats:td>\n<jats:td>(11\/336)<\/jats:td>\n<jats:td>(75\/336)<\/jats:td>\n<jats:td>(59\/84)<\/jats:td>\n<\/jats:tr>\n<jats:tr>\n<jats:td>120<\/jats:td>\n<jats:td>Saline<\/jats:td>\n<jats:td>42<\/jats:td>\n<jats:td>32<\/jats:td>\n<jats:td>34<\/jats:td>\n<jats:td>77<\/jats:td>\n<\/jats:tr>\n<jats:tr>\n<jats:td>(81\/192)<\/jats:td>\n<jats:td>(61\/192)<\/jats:td>\n<jats:td>(65\/192)<\/jats:td>\n<jats:td>(37\/48)<\/jats:td>\n<\/jats:tr>\n<\/jats:tbody>\n<\/jats:table>\n\n<jats:table-wrap-foot>\n<jats:fn><jats:p>Significant differences from the saline group, <jats:styled-content>*, <jats:italic>p<\/jats:italic>\u2003&lt;\u20030.02, <\/jats:styled-content><jats:styled-content>**, <jats:italic>p<\/jats:italic>\u2003&lt;\u20030.01, <\/jats:styled-content><jats:styled-content>***, <jats:italic>p<\/jats:italic>\u2003&lt;\u20030.001 (chi\u2010square test).<\/jats:styled-content><\/jats:p><\/jats:fn>\n<jats:fn><jats:p>Significant differences from the alendronate group at 60\u2003d, <jats:styled-content>###, <jats:italic>p<\/jats:italic>\u2003&lt;\u20030.001 (chi\u2010square test).<\/jats:styled-content><\/jats:p><\/jats:fn>\n<jats:fn><jats:p>Data in parenthesis represent the number of sites with each symptom\/total number of analyzed sites.<\/jats:p><\/jats:fn>\n<jats:fn><jats:p>\n                        In one rat of the saline group at 60\u2003d, ankylosis and pulp mineralization could not be evaluated because of severe root resorption.<\/jats:p><\/jats:fn>\n<\/jats:table-wrap-foot>\n<\/jats:table-wrap><\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The inhibitory effects of topical alendronate were retained on root and bone resorption, but not on ankylosis and pulp mineralization, in the replanted teeth for 4\u2003mo. Alendronate might also stimulate bone formation around the rat replanted teeth.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2007.01012.x","type":"journal-article","created":{"date-parts":[[2007,8,24]],"date-time":"2007-08-24T13:40:16Z","timestamp":1187962816000},"page":"194-200","source":"Crossref","is-referenced-by-count":28,"title":["Long\u2010term effects of local pretreatment with alendronate on healing of replanted rat teeth"],"prefix":"10.1111","volume":"43","author":[{"given":"K.","family":"Komatsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Shibata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Shimoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Oida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kawasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nifuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,24]]},"reference":[{"key":"e_1_2_6_2_2","volume-title":"Textbook and Color Atlas of Traumatic Injuries to the Teeth","author":"Andreassen JO","year":"1994"},{"key":"e_1_2_6_3_2","first-page":"21","volume-title":"Autotransplantation of Teeth","author":"Tsukiboshi M","year":"2001"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-9657.2001.017003120.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00755.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2005.06.025"},{"key":"e_1_2_6_7_2","volume-title":"Bisphosphonates in Bone Disease: from the Laboratory to the Patient","author":"Fleish H","year":"2000"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/8756-3282(95)00445-9"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(65)90077-4"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345960750090501"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5484.1508"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ejo\/26.5.469"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI115539"},{"key":"e_1_2_6_14_2","first-page":"121","article-title":"Clodronate stimulates bone formation as well as inhibits bone resorption and increases bone mineral density in rats fed a low\u2010calcium diet","volume":"50","author":"Horie D","year":"2003","journal-title":"J Med Dent Sci"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-001-2066-y"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2003.11.024"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2005.04.059"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-9657.2004.00244.x"},{"key":"e_1_2_6_19_2","first-page":"637","article-title":"Occlusal forces promote periodontal healing of transplanted teeth and prevent dentoalveolar ankylosis: an experimental study in rats","volume":"75","author":"Mine K","year":"2005","journal-title":"Angle Orthod"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0765.2007.01012.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0765.2007.01012.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T01:15:10Z","timestamp":1696986910000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0765.2007.01012.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,24]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1111\/j.1600-0765.2007.01012.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0765.2007.01012.x","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,24]]}}}