{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T19:12:05Z","timestamp":1774379525493,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T00:00:00Z","timestamp":1192665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Endothelin\u20101 is a 21\u2010amino\u2010acid peptide with multifunctional regulation. Initial research indicated that endothelin\u20101 levels in the gingival crevicular fluid from patients with chronic periodontitis were higher than those in the gingival crevicular fluid from healthy subjects. The aim of the present study was to assess the relationship between the clinical parameters and the concentrations of endothelin\u20101 within the gingival crevicular fluid from inflamed gingiva and periodontitis sites and, subsequently, after the treatment of periodontitis sites.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> A total of 60 subjects were divided into three groups \u2013 healthy (group I), gingivitis (group II) and chronic periodontitis (group III) \u2013 based on gingival index, pocket probing depth and clinical attachment loss. A fourth group consisted of 20 subjects from group III, 6\u20138\u2003wk after treatment (i.e. scaling and root planing). Gingival crevicular fluid samples collected from each patient were quantified for endothelin\u20101 using an enzymatic immunometric assay.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Endothelin\u20101 was not detected in any sample from any of the study groups.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The results showed that all the gingival crevicular fluid samples were negative for the endothelin\u20101 molecule. Therefore, endothelin\u20101 cannot be considered as a potential biomarker of periodontal disease progression.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2007.01026.x","type":"journal-article","created":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T13:06:43Z","timestamp":1192712803000},"page":"275-278","source":"Crossref","is-referenced-by-count":12,"title":["Crevicular fluid endothelin\u20101 levels in periodontal health and disease"],"prefix":"10.1111","volume":"43","author":[{"given":"A. R.","family":"Pradeep","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. N.","family":"Guruprasad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Swati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Shikha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,21]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1985.248.5.C550"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/332411a0"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(89)90011-4"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)63795-0"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489609137873"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.81.4.1415"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1681\/ASN.V371398","article-title":"Glomerular epithelial cells produce endothelin\u20101","volume":"3","author":"Cybulsky AV","year":"1993","journal-title":"J Am Soc Nephrol"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1994.tb00243.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.0578"},{"key":"e_1_2_5_11_2","first-page":"631","article-title":"Endothelin\u20101 and intraocular inflammation in pigmented rabbit eyes","volume":"99","author":"Shoji N","year":"1995","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)81590-6"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02419.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS103S327S"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.00668.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00754.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.00653.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016356309011240"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12349932"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12483000"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(91)91461-K"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9969(92)90011-V"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0765.2007.01026.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0765.2007.01026.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T02:27:30Z","timestamp":1696991250000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0765.2007.01026.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,21]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1111\/j.1600-0765.2007.01026.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0765.2007.01026.x","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,21]]}}}