{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:26:51Z","timestamp":1762100811504},"reference-count":59,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,6,9]],"date-time":"2008-06-09T00:00:00Z","timestamp":1212969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> The purpose of this study was to determine any difference between <jats:italic>Porphyromonas gingivalis<\/jats:italic> isolates from periodontally healthy sites as compared to those from diseased sites with respect to the ability to invade host cells.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Subgingival plaque samples were obtained from periodontally healthy and diseased sites using paper points. <jats:italic>P<\/jats:italic>.<jats:italic>\u2003gingivalis<\/jats:italic> colonies were isolated and tested, using an antibiotic protection assay, for their ability to invade KB cells. <jats:italic>P.\u2003gingivalis<\/jats:italic> 381 and <jats:italic>Escherichia coli<\/jats:italic> MC1061 were used as controls.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Mean values of 16.79\u2003\u00b1\u20030.86\u2003\u00d7\u200310<jats:sup>3<\/jats:sup>\u2003colony\u2010forming units\/mL and 26.14\u2003\u00b1\u20032.11\u2003\u00d7\u200310<jats:sup>3<\/jats:sup>\u2003colony\u2010forming units\/mL were observed in invasion assays for isolates from periodontally healthy and diseased sites, respectively. <jats:italic>P<\/jats:italic>.<jats:italic>\u2003gingivalis<\/jats:italic> present in diseased sites had significantly greater invasive abilities than strains isolated from healthy sites. No statistical difference was noted between male or female subjects concerning the degree of invasion; isolates from diseased sites from both genders had significantly greater invasion abilities than those from healthy sites. A significant correlation was found between the increased invasive capabilities of <jats:italic>P<\/jats:italic>.\u2003<jats:italic>gingivalis<\/jats:italic> isolates vs. an increased probing depth.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The increased invasion noted with <jats:italic>P<\/jats:italic>.\u2003<jats:italic>gingivalis<\/jats:italic> isolates from diseased sites vs. healthy sites, and the increased invasive capabilities with increasing probing depth, indicate that <jats:italic>P<\/jats:italic>.\u2003<jats:italic>gingivalis<\/jats:italic> isolates have a varying ability to invade host cells in the periodontal pocket.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2007.01064.x","type":"journal-article","created":{"date-parts":[[2008,6,10]],"date-time":"2008-06-10T04:35:29Z","timestamp":1213072529000},"page":"524-530","source":"Crossref","is-referenced-by-count":20,"title":["Invasive differences among <i>Porphyromonas gingivalis<\/i> strains from healthy and diseased periodontal sites"],"prefix":"10.1111","volume":"43","author":[{"given":"K. 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