{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:31:50Z","timestamp":1789810310549,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2009,2,6]],"date-time":"2009-02-06T00:00:00Z","timestamp":1233878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p>\n                    <jats:bold>Background and Objective:\u2002<\/jats:bold>\n                    Periodontal disease is an inflammatory condition of tooth\u2010supporting tissues. Arachidonic acid metabolites have been implicated in development of periodontal disease, especially those derived from the cyclo\u2010oxygenase (COX) pathway. This study investigated the role of inhibitors of cyclo\u2010oxygenases (COX\u20101 and COX\u20102) in a model of periodontal disease in rats.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Material and Methods:\u2002<\/jats:bold>\n                    A ligature was placed around the molar of rats. Losses of fiber attachment and of alveolar bone were measured morphometrically in histologically prepared sections. Infiltration of cells into gingival tissue surrounding the ligated tooth was also determined.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    Systemic and local administration of non\u2010selective and selective COX\u20102 inhibitors, preventively, resulted in significant reduction of the losses of fiber attachment and alveolar bone, as well as decreased leukocyte numbers in gingival tissue. Preventive selective inhibition of COX\u20101 was as effective as COX\u20102 inhibition in reducing local fiber attachment loss and cell migration, but did not prevent alveolar bone loss.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:\u2002<\/jats:bold>\n                    Our results provide evidence for participation of COX\u20101 and COX\u20102 in early stages of periodontal disease in rats. Furthermore, local administration of COX inhibitors reduced the signs of periodontal disease to the same extent as systemic treatment. Therapeutic approaches incorporating locally delivered anti\u2010inflammatory drugs could be of benefit for patients suffering from periodontal disease.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0765.2007.01069.x","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T01:55:09Z","timestamp":1233971709000},"page":"153-160","source":"Crossref","is-referenced-by-count":35,"title":["Role of systemic and local administration of selective inhibitors of cyclo\u2010oxygenase\u20031 and 2 in an experimental model of periodontal disease in rats"],"prefix":"10.1111","volume":"44","author":[{"given":"C. M.","family":"Queiroz\u2010Junior","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. M. F.","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. L. 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N.","family":"Francischi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,20]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00199.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910308200202"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1986.tb01443.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1929"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.52.33157"},{"key":"e_1_2_6_7_2","first-page":"7908","article-title":"Cyclooxygenases 1 and 2","volume":"18","author":"Vane JR","year":"1998","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-006-9013-z"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi992551b"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.6.1009"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01391-1"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.9.1030"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1996.tb00516.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.74.4.2402-2414.2006"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1982.tb01153.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2006.12.012"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2004.01.004"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704937"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.09.055"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2006.02.012"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2000.2240112.x"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2004.04.004"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1984.55.9.536"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/newbio231232a0"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200108093450607"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.12.1754"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2004.12.018"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.1.57"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2001.360203.x"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.22.13313"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-6618(03)00188-9"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2004.05.002"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-5346com"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0765.2007.01069.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0765.2007.01069.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T05:56:48Z","timestamp":1697263008000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0765.2007.01069.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,20]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1111\/j.1600-0765.2007.01069.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0765.2007.01069.x","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,20]]}}}