{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:38:03Z","timestamp":1760888283158},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T00:00:00Z","timestamp":1218672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Human Fc\u03b3RIIB is one of the receptors for immunoglobulin\u2003G (IgG) and suppresses the activation of B\u2003lymphocytes through cross\u2010linking with the B\u2003cell receptor via immune complexes. This function of Fc\u03b3RIIB is essential for the negative regulation of antibody production. Our previous study has demonstrated the gene polymorphism Fc\u03b3RIIB\u2010I232T to be associated with periodontitis. The polymorphism Fc\u03b3RIIB\u2010232T has been reported to inhibit B\u2010cell antigen receptor signaling more effectively compared to Fc\u03b3RIIB\u2010232I, while other groups concluded that Fc\u03b3RIIB\u2010232T had no ability to inhibit activatory receptors. In this study, we examined whether Fc\u03b3RIIB\u2010I232T polymorphism would change the IgG antibody response to the periodontopathic bacteria <jats:italic>Porphyromonas gingivalis<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Forty\u2010seven patients with periodontitis were genotyped with the direct sequencing of genome DNA. Serum IgG and specific IgG subclass levels for the sonicate of <jats:italic>P.\u2003gingivalis<\/jats:italic> and the recombinant 40\u2003kDa outer membrane protein (OMP) were determined.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> No significant difference in the total IgG level and IgG response to <jats:italic>P.\u2003gingivalis<\/jats:italic> sonicate were observed between sera from Fc\u03b3RIIB\u2010232T carriers and non\u2010carriers. The Fc\u03b3RIIB\u2010232T carriers revealed a significantly lower IgG<jats:sub>2<\/jats:sub> response to <jats:italic>P.\u2003gingivalis<\/jats:italic> 40\u2003kDa OMP compared to non\u2010carriers (<jats:italic>p\u2003<\/jats:italic>=<jats:italic>\u2003<\/jats:italic>0.04, Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test). Lower responses of Fc\u03b3RIIB\u2010232T carriers were also observed in specific IgG and IgG<jats:sub>1<\/jats:sub> levels. The Fc\u03b3RIIB\u2010232T carriers revealed a low level of IgG<jats:sub>2<\/jats:sub> response to <jats:italic>P.\u2003gingivalis<\/jats:italic> 40\u2003kDa OMP, even with a high average probing pocket depth.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These results suggest that association of the Fc\u03b3RIIB\u2010232T allele with periodontitis might be related to the lower levels of antibody response to <jats:italic>P.\u2003gingivalis<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2007.01078.x","type":"journal-article","created":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T10:21:52Z","timestamp":1218709312000},"page":"706-711","source":"Crossref","is-referenced-by-count":7,"title":["Lower antibody response to <i>Porphyromonas gingivalis<\/i> associated with immunoglobulin\u2003G Fc\u03b3 receptor\u2003II<i>B<\/i> polymorphism"],"prefix":"10.1111","volume":"43","author":[{"given":"Y.","family":"Honma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Sugita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Abiko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Yoshie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,11,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/368070a0"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"30636","DOI":"10.1016\/S0021-9258(18)43861-6","article-title":"Tyrosine\u2010containing sequence 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