{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T10:31:51Z","timestamp":1789813911506,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,7,4]],"date-time":"2008-07-04T00:00:00Z","timestamp":1215129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> B lymphocyte is the dominant infiltrating cell type in periodontitis lesions. CXCL13, produced by follicular dendritic cells, endothelial cells and fibroblasts, is crucial for B\u2010cell trafficking. An association between chronic inflammation and lymphoid organogenesis has been reported in infection and in autoimmune responses, in which T\u2010cell\/B\u2010cell follicles with a follicular dendritic cell network are formed. The aim of this study was to examine CXCL13 expression and follicular dendritic cell distribution in relation to B\u2010cell infiltration in chronic inflammatory periodontal lesions.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Fifty\u2010eight gingival tissue biopsies from patients with periodontitis and 25 samples from subjects with gingivitis were analyzed. Gene expression for CXCL13 and for the CD21 long isoform was analyzed using the reverse transcription\u2013polymerase chain reaction. Immunohistochemical analysis was performed using antibodies to CXCL13, CXCR5, follicular dendritic cells, CD3 and CD19 on serial cryostat sections.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> mRNA for CXCL13 was expressed in both periodontitis and gingivitis tissues. The number of CXCL13<jats:sup>+<\/jats:sup> cells was significantly higher in periodontitis than in gingivitis in connective tissues subjacent to the pocket epithelium and positively correlated with the number of CD19<jats:sup>+<\/jats:sup> cells. CXCL13<jats:sup>+<\/jats:sup> cells were distributed in B\u2010cell\u2010dominant areas both with and without follicular dendritic cells. Although obvious reticular networks of follicular dendritic cells were not found in periodontitis and gingivitis, the accumulation of follicular dendritic cells in B\u2010cell\u2010dominant areas in periodontitis was observed in some patients.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These findings suggested that CXCL13 and follicular dendritic cells were involved in B\u2010cell recruitment to, and B\u2010cell distribution in, chronic inflammatory periodontal lesions.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2008.01042.x","type":"journal-article","created":{"date-parts":[[2008,7,6]],"date-time":"2008-07-06T01:15:25Z","timestamp":1215306925000},"page":"635-641","source":"Crossref","is-referenced-by-count":28,"title":["CXCL13 expression and follicular dendritic cells in relation to B\u2010cell infiltration in periodontal disease 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