{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T17:34:18Z","timestamp":1773423258080,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T00:00:00Z","timestamp":1223337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold>Visible, near\u2010infrared (optical) spectroscopy can be used to measure regional tissue hemodynamics and edema and therefore may represent an ideal tool with which to study periodontal inflammation in a noninvasive manner. The study objective was to evaluate the ability of optical spectroscopy to determine simultaneously multiple inflammatory indices (tissue oxygenation, total tissue hemoglobin, deoxyhemoglobin, oxygenated hemoglobin and tissue edema) in periodontal tissues<jats:italic>in vivo<\/jats:italic>.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold>Spectra were obtained, processed and evaluated from healthy, gingivitis and periodontitis sites (<jats:italic>n<\/jats:italic><jats:bold><jats:italic>\u2003<\/jats:italic><\/jats:bold>=\u2003133) using a portable optical, near\u2010infrared spectrometer. A modified Beer\u2013Lambert unmixing model that incorporates a nonparametric scattering loss function was used to determine the relative contribution of each inflammatory component to the overall spectrum.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>Optical spectroscopy was harnessed to generate complex inflammatory profiles of periodontal tissues. Tissue oxygenation at periodontitis sites was significantly decreased (<jats:italic>p\u2003<\/jats:italic>&lt;\u20030.05) compared to sites with gingivitis and healthy controls. This was largely the result of an increase in deoxyhemoglobin in the periodontitis sites compared with healthy (<jats:italic>p\u2003<\/jats:italic>&lt;\u20030.01) and gingivitis (<jats:italic>p\u2003<\/jats:italic>=\u20030.05) sites. Tissue water content<jats:italic>per se<\/jats:italic>showed no significant difference between the sites, but a water index associated with tissue electrolyte levels and temperature differed significantly between periodontitis sites and both healthy and gingivitis sites (<jats:italic>p\u2003<\/jats:italic>&lt;\u20030.03).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold>This study established that optical spectroscopy can simultaneously determine multiple inflammatory indices directly in the periodontal tissues<jats:italic>in vivo<\/jats:italic>. Visible, near\u2010infrared spectroscopy has the potential to be developed into a simple, reagent\u2010free, user\u2010friendly, chairside, site\u2010specific, diagnostic and prognostic test for periodontitis.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2008.01112.x","type":"journal-article","created":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T07:04:12Z","timestamp":1223363052000},"page":"117-124","source":"Crossref","is-referenced-by-count":28,"title":["<i>In vivo<\/i>determination of multiple indices of periodontal inflammation by optical spectroscopy"],"prefix":"10.1111","volume":"44","author":[{"given":"K. Z.","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"X. M.","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Man","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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