{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:37:49Z","timestamp":1760888269128},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T00:00:00Z","timestamp":1223337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Familial Mediterranean fever stimulates a very intense acute\u2010phase reactants response and if left untreated eventually leads to amyloidosis. The aim of this study was to determine the prevalence of periodontal disease among patients with familial Mediterranean fever in the Black Sea region in Turkey and to evaluate whether periodontitis is related to amyloidosis in patients with familial Mediterranean fever.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> One\u2010hundred and thirty three patients with familial Mediterranean fever and 50 healthy subjects were included in this study. Periodontal health and disease were evaluated using the gingival index, papillary bleeding index, plaque index and periodontal disease index. The concentrations of serum acute\u2010phase reactants were measured at baseline and at 4\u20136\u2003wk after completion of the nonsurgical periodontal therapy. Genetic testing for familial Mediterranean fever was performed using the familial Mediterranean fever StripAssay. Kidney biopsy was carried out on all proteinuric patients.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The prevalence of moderate to severe periodontitis in familial Mediterranean fever patients with amyloidosis (80.6%) was significantly greater (<jats:italic>p\u2003<\/jats:italic>&lt;\u20030.01) than in familial Mediterranean fever patients without amyloidosis (38%) and in controls (20%). Serum levels of acute\u2010phase reactants in familial Mediterranean fever patients were reduced significantly following nonsurgical periodontal therapy (<jats:italic>p\u2003<\/jats:italic>&lt;\u20030.01).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Periodontal therapy seems to reduce the serum levels of acute\u2010phase reactants in patients with familial Mediterranean fever. Therefore, treating periodontitis might help to alleviate the disease burden in patients with familial Mediterranean fever.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2008.01115.x","type":"journal-article","created":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T07:06:10Z","timestamp":1223363170000},"page":"354-361","source":"Crossref","is-referenced-by-count":14,"title":["Periodontal disease in patients with familial Mediterranean fever: from inflammation to amyloidosis"],"prefix":"10.1111","volume":"44","author":[{"given":"M. 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