{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:42:41Z","timestamp":1792093361544,"version":"4.4.0"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,2,6]],"date-time":"2009-02-06T00:00:00Z","timestamp":1233878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Single nucleotide polymorphisms are assumed to be associated with the differential production of cytokines. We evaluated gene polymorphisms of interleukin\u201010 (\u2212592C&gt;A, \u2212819C&gt;T and \u22121082G&gt;A) and interleukin\u201012B (+16974) in patients with chronic periodontitis (<jats:italic>n\u2003<\/jats:italic>=\u2003145) and generalized aggressive periodontitis (<jats:italic>n\u2003<\/jats:italic>=\u200365) in comparison with healthy controls (<jats:italic>n\u2003<\/jats:italic>=\u2003126).<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Gene promoter polymorphisms were analyzed by polymerase chain reaction with sequence\u2010specific primers. Genotype and allele frequencies were analyzed using the chi\u2010square test and logistic regression analysis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The interleukin\u201010 \u2212592 polymorphism showed significant differences among the three groups (<jats:italic>p\u2003<\/jats:italic>=\u20030.0330). The genotype frequencies of the \u2212592 locus between the chronic periodontitis and healthy control groups were significantly different (AC vs. AA: odds ratio\u2003=\u20030.33). The combination ATA\/ATA seemed to be associated with susceptibility to generalized aggressive periodontitis (<jats:italic>p\u2003<\/jats:italic>=\u20030.0276). Patients with the composite ATA\/ACC were less likely to develop chronic periodontitis (<jats:italic>p\u2003<\/jats:italic>=\u20030.0248). The CC genotype of interleukin\u201012B (+16974) was related to chronic periodontitis (CC vs. AA, <jats:italic>p\u2003<\/jats:italic>=\u20030.0211; CC vs. AA+AC, <jats:italic>p\u2003<\/jats:italic>=\u20030.0187). The AC heterozygosity of interleukin\u201012B was significantly lower in chronic periodontitis vs. healthy controls (<jats:italic>p\u2003<\/jats:italic>=\u20030.0500).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The interleukin\u201010 gene polymorphism at position \u2212592C&gt;A may be associated with a lower risk for development of chronic periodontitis. The interleukin\u201010 haplotype ATA is associated with generalized aggressive periodontitis. On the other hand, interleukin\u201012B genetic variants at position +16974 are associated with susceptibility to chronic periodontitis.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2008.01116.x","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T06:55:50Z","timestamp":1233989750000},"page":"378-385","source":"Crossref","is-referenced-by-count":37,"title":["Interleukin\u201010 (\u2212592 C\/A) and interleukin\u201012B (+16974 A\/C) gene polymorphisms and the interleukin\u201010 ATA haplotype are associated with periodontitis in a Taiwanese 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