{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:35:00Z","timestamp":1780414500766,"version":"3.54.1"},"reference-count":75,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,2,6]],"date-time":"2009-02-06T00:00:00Z","timestamp":1233878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Periodontitis is a risk factor for the development of atherosclerosis. Recent studies indicate that oxidative mechanisms, including lipid peroxidation, are involved not only in periodontitis but also in atherosclerosis. Lipid peroxidation may play an important role in the pathogenesis of atherosclerosis, particularly during its earliest stages. The purpose of this study was to investigate the relationship between lipid peroxidation induced by periodontitis and the initiation of atherosclerosis.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Sixteen rats were randomly divided into two groups of eight rats each. Periodontitis was ligature\u2010induced for 4\u2003wk in the experimental group, whereas the control group was left untreated. After the experimental period, the mandibular first molar regions were resected and then subjected to histological analysis and measurement of hexanoyl\u2010lysine expression as an indicator of lipid peroxidation. Descending aorta was used for measuring the levels of hexanoyl\u2010lysine, reactive oxygen species and lipid deposits, and for real\u2010time polymerase chain reaction microarray analysis. The level of hexanoyl\u2010lysine was also measured in serum.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In the experimental group, the levels of hexanoyl\u2010lysine in periodontal tissue and serum increased. Only aorta samples in the experimental group showed lipid accumulation, with increased expression of hexanoyl\u2010lysine, reactive oxygen species and oxidative stress\u2010related genes (including nitric oxide synthases 2 and 3), whereas the superoxide dismutase 1 gene level was down\u2010regulated.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> In a ligature\u2010induced periodontitis rat model, increased lipid peroxidation was found in serum and aorta as well as in periodontal tissue. Atherosclerosis\u2010related gene expression and histological changes were also stimulated. Periodontitis\u2010induced lipid peroxidation in the aorta may be involved in the early stage of atherosclerosis.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2008.01122.x","type":"journal-article","created":{"date-parts":[[2009,2,7]],"date-time":"2009-02-07T06:56:31Z","timestamp":1233989791000},"page":"434-442","source":"Crossref","is-referenced-by-count":47,"title":["Periodontitis\u2010induced lipid peroxidation in rat descending aorta is involved in the initiation of 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