{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:01:21Z","timestamp":1770966081525,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T00:00:00Z","timestamp":1223337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> The level of Substance\u2010P in gingival crevicular fluid has been found to correlate with clinical measures of periodontal disease. The present study was designed to assess the relationship between clinical parameters and levels of Substance\u2010P in the gingival crevicular fluid from inflamed gingiva, periodontitis sites and after treatment of periodontitis sites, and to correlate them to the Substance\u2010P levels of plasma.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Thirty, age\u2010 and gender\u2010matched subjects were divided into three groups (healthy, gingivitis and chronic periodontitis) based on modified gingival index scores and clinical attachment loss. A fourth group consisted of 10 subjects from the periodontitis group, 6\u20138\u2003wk after initial therapy. Plasma and gingival crevicular fluid samples were collected and quantified for Substance\u2010P using an enzyme immunoassay.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The mean concentration of Substance\u2010P, both in gingival crevicular fluid and plasma, was observed to be highest in the periodontitis group (45.13\u2003pg\/mL in gingival crevicular fluid and 67.8\u2003pg\/mL in plasma) and lowest in the healthy group (6.07\u2003pg\/mL in gingival crevicular fluid and below the detection level in plasma). The mean Substance\u2010P concentration in the gingivitis group (11.42 pg\/mL in gingival crevicular fluid and 38.8\u2003pg\/mL in plasma) and in the after\u2010treatment group (7.58\u2003pg\/mL in gingival crevicular fluid and 39.7\u2003pg\/mL in plasma) lay between the highest and lowest values. In all groups the gingival crevicular fluid levels showed a statistically significant positive correlation with that of plasma and clinical attachment loss.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Substance\u2010P levels were highest in the gingival crevicular fluid from sites with periodontal destruction; however, periodontal treatment resulted in the reduction of Substance\u2010P levels. Gingival crevicular fluid and plasma Substance\u2010P levels showed a positive correlation in all of the groups.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2008.01138.x","type":"journal-article","created":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T07:07:22Z","timestamp":1223363242000},"page":"232-237","source":"Crossref","is-referenced-by-count":24,"title":["Gingival crevicular fluid and plasma levels of neuropeptide Substance\u2010P in periodontal health, disease and after nonsurgical therapy"],"prefix":"10.1111","volume":"44","author":[{"given":"A. R.","family":"Pradeep","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Raj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Aruna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Chowdhry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,20]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199002083220606"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb02162.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(94)E0017-B"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01192.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.1997.270-ce1162.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.10.1528"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/ar1503"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-3623(97)00078-5"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12469898"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1177\/154411130401500203"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2002.310309.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1998.1248"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.7.974"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027004262.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027007526.x"},{"key":"e_1_2_5_17_2","first-page":"3","article-title":"A modified gingival index for use in clinical trials","volume":"8","author":"Lobene RR","year":"1986","journal-title":"Clin Prev Dent"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345690480011501"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1994.65.12.1113"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0765.2008.01138.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0765.2008.01138.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T09:56:50Z","timestamp":1697277410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0765.2008.01138.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,20]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["10.1111\/j.1600-0765.2008.01138.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0765.2008.01138.x","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,20]]}}}