{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:07:18Z","timestamp":1789927638524,"version":"4.0.1"},"reference-count":74,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T00:00:00Z","timestamp":1223337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p>Theantiquity and severity of periodontal diseases are demonstrated by the hard evidence of alveolar bone loss in gnathic remains of the Pliocene\/Pleistocene deposits of the Bloubank Valley at Sterkfontein, Swartkrans and Kromdrai in South Africa. Extant Homo has characterized and cloned a superfamily of proteins which include the bone morphogenetic proteins that regulate tooth morphogenesis at different stages of development as temporally and spatially connected events. The induction of cementogenesis, periodontal ligament and alveolar bone regeneration are regulated by the co\u2010ordinated expression of bone morphogenetic proteins. Naturally derived and recombinant human bone morphogenetic proteins induce periodontal tissue regeneration in mammals. Morphological analyses on undecalcified sections cut at 3\u20136\u2003\u03bcm on a series of mandibular molar Class\u2003II and III furcation defects induced in the non\u2010human primate <jats:italic>Papio ursinus<\/jats:italic> show the induction of cementogenesis. Sharpey\u2019s fibers nucleate as a series of composite collagen bundles within the cementoid matrix in close relation to embedded cementocytes. Osteogenic protein\u20101 and bone morphogenetic protein\u20102 possess a structure\u2013activity profile, as shown by the morphology of tissue regeneration, preferentially cementogenic and osteogenic, respectively. In <jats:italic>Papio ursinus<\/jats:italic>, transforming growth factor\u2010\u03b2<jats:sub>3<\/jats:sub> also induces cementogenesis, with Sharpey\u2019s fibers inserting into newly formed alveolar bone. Capillary sprouting and invasion determine the sequential insertion and alignment of individual collagenic bundles. The addition of responding stem cells prepared by finely mincing fragments of autogenous <jats:italic>rectus abdominis<\/jats:italic> muscle significantly enhances the induction of periodontal tissue regeneration when combined with transforming growth factor\u2010\u03b2<jats:sub>3<\/jats:sub> implanted in Class\u2003II and III furcation defects of <jats:italic>Papio ursinus<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2008.01158.x","type":"journal-article","created":{"date-parts":[[2008,10,7]],"date-time":"2008-10-07T07:40:17Z","timestamp":1223365217000},"page":"141-152","source":"Crossref","is-referenced-by-count":27,"title":["Cementogenesis and the induction of periodontal tissue regeneration by the osteogenic proteins of the transforming growth factor\u2010\u03b2 superfamily"],"prefix":"10.1111","volume":"44","author":[{"given":"U.","family":"Ripamonti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u2010C.","family":"Petit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Teare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,2,20]]},"reference":[{"key":"e_1_2_9_2_2","first-page":"375","volume-title":"Extracellular Matrix Biochemistry","author":"Reddi AH","year":"1984"},{"key":"e_1_2_9_3_2","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1042\/bst0280345","article-title":"Morphogenetic messages are in the extracellular matrix: biotechnology from bench to bedside","volume":"28","author":"Reddi AH","year":"2000","journal-title":"Biochem Soc Trans"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80193-2"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1952.0012"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1089\/107632700418074"},{"key":"e_1_2_9_7_2","first-page":"147","article-title":"Symbiosis of biotechnology and biomaterials: applications in tissue engineering of bone and cartilage","volume":"65","author":"Reddi AH","year":"1994","journal-title":"J Cell Biochem"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0398-247"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03470140065025"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/term.24"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1089\/ten.2006.0167"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajpa.1330760208"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1989.60.2.118"},{"key":"e_1_2_9_14_2","first-page":"141","article-title":"The hard periodontal tissues of the Australopithecinae","volume":"19","author":"Ripamonti U","year":"1989","journal-title":"Proc of Electr Micros Soc South Afr"},{"key":"e_1_2_9_15_2","first-page":"391","article-title":"\u00c9vidence de maladies parodontales chez les Australopith\u00e8ques r\u00e9v\u00e9l\u00e9e par \u013eexamen de restes osseux fossilis\u00e9s","volume":"95","author":"Ripamonti U","year":"1991","journal-title":"\u013d Anthropologie"},{"key":"e_1_2_9_16_2","volume-title":"The South African Fossil Ape\u2010Man: The Australopithecinae. 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