{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T18:07:45Z","timestamp":1789927665548,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1838,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1111\/j.1600-0765.2010.01278.x","type":"journal-article","created":{"date-parts":[[2010,6,10]],"date-time":"2010-06-10T19:54:46Z","timestamp":1276199686000},"page":"635-642","source":"Crossref","is-referenced-by-count":90,"title":["Levels of Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, inflammatory cytokines and species-specific immunoglobulin G in generalized aggressive and chronic periodontitis"],"prefix":"10.1111","volume":"45","author":[{"given":"R. C. V.","family":"Casarin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9.","family":"Del Peloso Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. S.","family":"Mariano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. H.","family":"Nociti Jr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Z.","family":"Casati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. B.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,20]]},"reference":[{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1902\/annals.1999.4.1.39","article-title":"Early-onset periodontitis","volume":"4","author":"Tonetti","year":"1999","journal-title":"Ann Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","article-title":"Development of a classification system for periodontal diseases and conditions","volume":"4","author":"Armitage","year":"1999","journal-title":"Ann Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB3|cit3","article-title":"Consensus report: aggressive periodontitis","volume":"4","author":"Lang","year":"1999","journal-title":"Ann Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/j.1600-051X.2005.00777.x","article-title":"Prevalence of periodontal pathogens in Brazilians with aggressive or chronic periodontitis","volume":"32","author":"Cortelli","year":"2005","journal-title":"J Clin Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1111\/j.1600-051X.2007.01080.x","article-title":"Aggregatibacter actinomycetemcomitans as indicator for aggressive periodontitis by two analysing strategies","volume":"34","author":"Schacher","year":"2007","journal-title":"J Clin Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.1600-0757.1999.tb00164.x","article-title":"Humoral immune response to Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in periodontal disease","volume":"20","author":"Kinane","year":"1999","journal-title":"Periodontol 2000"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1600-0765.2005.00860.x","article-title":"Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis subgingival presence, species-specific serum immunoglobulin G antibody levels, and periodontitis disease recurrence","volume":"41","author":"Rams","year":"2006","journal-title":"J Periodontal Res"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1034\/j.1399-302X.1999.140205.x","article-title":"Oral and systemic immunoglobulin G-subclass antibodies to Actinobacillus actinomycetemcomitans leukotoxin","volume":"14","author":"Engstrom","year":"1999","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1034\/j.1399-302X.2001.160402.x","article-title":"Functional characteristics of antibodies induced by Arg-gingipain (HRgpA) and Lys-gingipain (Kgp) from Porphyromonas gingivalis","volume":"16","author":"Nakagawa","year":"2001","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"2858","DOI":"10.1128\/IAI.69.5.2858-2864.2001","article-title":"Arg-gingipain a DNA vaccine induces protective immunity against infection by Porphyromonas gingivalis in a murine model","volume":"69","author":"Yonezawa","year":"2001","journal-title":"Infect Immun"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1034\/j.1600-051X.2002.290905.x","article-title":"Analysis of genetic polymorphisms at the interleukin-10 loci in aggressive and chronic periodontitis","volume":"29","author":"Gonzales","year":"2002","journal-title":"J Clin Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1177\/154411130301400605","article-title":"Genes and gene polymorphisms associated with periodontal disease","volume":"14","author":"Kinane","year":"2003","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/j.1600-0757.2007.00214.x","article-title":"Cytokines and inflammatory factors regulating immunoglobulin production in aggressive periodontitis","volume":"45","author":"Schenkein","year":"2007","journal-title":"Periodontol 2000"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1902\/jop.2001.72.3.275","article-title":"A 2-step non-surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis","volume":"72","author":"Sigusch","year":"2001","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1902\/jop.2005.76.12.2276","article-title":"Cytokine profiles in peripheral blood and whole blood cell cultures associated with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis","volume":"76","author":"Havemose-Poulsen","year":"2005","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1601-0825.2008.01491.x","article-title":"TNF-alpha and IL-4 levels in generalized aggressive periodontitis subjects","volume":"15","author":"Bastos","year":"2008","journal-title":"Oral Dis"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1902\/jop.2001.72.5.590","article-title":"Expression of cytokines and inducible nitric oxide synthase in inflamed gingival tissue","volume":"72","author":"Hirose","year":"2001","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1128\/AEM.24.4.638-644.1972","article-title":"Survival of human dental plaque flora in various transport media","volume":"24","author":"Syed","year":"1972","journal-title":"Appl Microbiol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1902\/jop.2000.71.10.1535","article-title":"Levels of interleukin-1b, -8 and -10 and RANTES in gingival crevicular fluid and cell populations in adult periodontitis patients and the effect of periodontal treatment","volume":"71","author":"Gamonal","year":"2000","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/j.1600-051X.2008.01292.x","article-title":"Periodontal debridement as a therapeutic approach for severe chronic periodontitis: a clinical, microbiological and immunological study","volume":"35","author":"Del Peloso Ribeiro","year":"2008","journal-title":"J Clin Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1099\/jmm.0.46212-0","article-title":"Identification of bacteria in endodontic infections by sequence analysis of 16SrDNA clone libraries","volume":"55","author":"Saito","year":"2006","journal-title":"J Med Microbiol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0022-1759(02)00218-1","article-title":"LightCycler qPCR optimization for low copy number target DNA","volume":"270","author":"Teo","year":"2002","journal-title":"J Immunol Method"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB23|cit23","first-page":"127","article-title":"Nuclear DNA content and genome size of trout and human","volume":"51","author":"Dolezel","year":"2003","journal-title":"Cytometry A"},{"issue":"Suppl. 3","key":"10.1111\/j.1600-0765.2010.01278.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1034\/j.1600-051X.29.s3.1.x","article-title":"Can presence or absence of periodontal pathogens distinguish between subjects with chronic and aggressive periodontitis? A systematic review","volume":"29","author":"Mombelli","year":"2002","journal-title":"J Clin Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/j.1600-0722.1997.tb00174.x","article-title":"Localized juvenile periodontitis and Actinobacillus actinomycetemcomitans in a Brazilian population","volume":"105","author":"Tinoco","year":"1997","journal-title":"Eur J Oral Sci"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1902\/jop.2005.76.2.289","article-title":"Prevalence of periodontopathic bacteria in aggressive periodontitis patients in a Chilean population","volume":"76","author":"Gajardo","year":"2005","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1902\/jop.2003.74.10.1460","article-title":"Prevalence of periodontopathic bacteria in aggressive periodontitis patients in a Japanese population","volume":"74","author":"Takeuchi","year":"2003","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1902\/jop.2007.060129","article-title":"Occurrence of periodontopathic and superinfecting bacteria in chronic and aggressive periodontitis subjects in a Colombian population","volume":"78","author":"Botero","year":"2007","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1111\/j.1600-051X.2006.01006.x","article-title":"Subgingival microbiota of periodontally untreated Mexican subjects with generalized aggressive periodontitis","volume":"33","author":"Ximenez-Fyvie","year":"2006","journal-title":"J Clin Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1902\/jop.2007.060187","article-title":"Demographic, clinical, and microbial aspects of chronic and aggressive periodontitis in Colombia: a multicenter study","volume":"78","author":"Lafaurie","year":"2007","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/j.1399-302X.2006.00296.x","article-title":"Immunoglobulin G subclass antibody profiles in Porphyromonas gingivalis-associated aggressive and chronic periodontitis patients","volume":"21","author":"Takeuchi","year":"2006","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0765.2005.00829.x","article-title":"Influence of proinflammatory cytokines on Actinobacillus actinomycetemcomitans specific IgG responses","volume":"41","author":"Tanaka","year":"2006","journal-title":"J Periodont Res"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1902\/jop.1990.61.7.412","article-title":"Serum antibodies to periodontal bacteria","volume":"61","author":"Gunsolley","year":"1990","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1128\/IAI.62.5.1677-1682.1994","article-title":"Serum immunoglobulin G subclass concentrations in periodontally healthy and diseased individuals","volume":"62","author":"Lu","year":"1994","journal-title":"Infect Immun"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1128\/IAI.60.5.1806-1812.1992","article-title":"Immunoglobulin G subclass response of localized juvenile periodontitis patients to Actinobacillus actinomycetemcomitans Y4 lipopolysaccharide","volume":"60","author":"Wilson","year":"1992","journal-title":"Infect Immun"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1128\/IAI.62.3.1026-1031.1994","article-title":"Immunization against Porphyromonas gingivalis inhibits progression of experimental periodontitis in nonhuman primates","volume":"62","author":"Persson","year":"1994","journal-title":"Infect Immun"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1902\/jop.1998.69.6.686","article-title":"Immunization with Porphyromonas gingivalis cysteine protease: effects on experimental gingivitis and ligature-induced periodontitis in Macaca fascicularis","volume":"69","author":"Moritz","year":"1998","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1128\/IAI.60.7.2926-2935.1992","article-title":"Immunization with Porphyromonas (Bacteroides) gingivalis fimbriae protects against periodontal destruction","volume":"60","author":"Evans","year":"1992","journal-title":"Infect Immun"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1128\/IAI.70.5.2480-2486.2002","article-title":"Immunization with the RgpA-Kgp proteinase-adhesin complexes of Porphyromonas gingivalis protects against periodontal bone loss in the rat periodontitis model","volume":"70","author":"Rajapakse","year":"2002","journal-title":"Infect Immun"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"7959","DOI":"10.1128\/IAI.69.12.7959-7963.2001","article-title":"Prevention of Porphyromonas gingivalis-induced oral bone loss following immunization with gingipain R1","volume":"69","author":"Gibson","year":"2001","journal-title":"Infect Immun"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1399-302X.1989.tb00399.x","article-title":"Experimental infections by Bacteroides gingivalis in non-immunized and immunized rabbits","volume":"4","author":"Dahle\u2019n","year":"1989","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB42|cit42","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1399-302X.2005.00208.x","article-title":"Elevated serum IgG titer and avidity to Actinobacillus actinomycetemcomitans serotype c in Japanese periodontitis patients","volume":"20","author":"Wang","year":"2005","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB43|cit43","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1177\/00220345000790060301","article-title":"Antigenic specificity of gingival crevicular fluid antibody to Actinobacillus actinomycetemcomitans","volume":"79","author":"Ebersole","year":"2000","journal-title":"J Dent Res"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB44|cit44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2370.1997.tb00001.x","article-title":"An investigation of polymorphism in the interleukin-10 gene promoter","volume":"24","author":"Turner","year":"1997","journal-title":"Eur J Immunogenet"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB45|cit45","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the interleukin-10 receptor","volume":"19","author":"Moore","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB46|cit46","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S1473-3099(06)70577-1","article-title":"The two faces of interleukin 10 in human infectious diseases","volume":"6","author":"Mege","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB47|cit47","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1093\/infdis\/174.5.994","article-title":"Interleukin-10 impairs host defense in murine pneumococcal pneumonia","volume":"174","author":"Van Der Poll","year":"1996","journal-title":"J Infect Dis"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB48|cit48","doi-asserted-by":"crossref","first-page":"722","DOI":"10.4049\/jimmunol.155.2.722","article-title":"Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumonia","volume":"155","author":"Greenberger","year":"1995","journal-title":"J Immunol"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB49|cit49","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S1473-3099(03)00741-2","article-title":"Latent tuberculosis: mechanisms of host and bacillus that contribute to persistent infection","volume":"3","author":"Tufariello","year":"2003","journal-title":"Lancet Infect Dis"},{"key":"10.1111\/j.1600-0765.2010.01278.x-BIB50|cit50","doi-asserted-by":"crossref","first-page":"4143","DOI":"10.1128\/IAI.64.10.4143-4147.1996","article-title":"Production of interleukin-10 and transforming growth factor beta by peripheral blood mononuclear cells in Q fever endocarditis","volume":"64","author":"Capo","year":"1996","journal-title":"Infect Immun"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0765.2010.01278.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1600-0765.2010.01278.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T15:09:03Z","timestamp":1711552143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0765.2010.01278.x"}},"subtitle":["Inflammatory patterns of aggressive and chronic periodontitis"],"short-title":[],"issued":{"date-parts":[[2010,8,20]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,10]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1600-0765.2010.01278.x","relation":{},"ISSN":["0022-3484"],"issn-type":[{"value":"0022-3484","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8,20]]}}}