{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T00:25:12Z","timestamp":1793060712178,"version":"4.5.0"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1805,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1111\/j.1600-0765.2010.01304.x","type":"journal-article","created":{"date-parts":[[2010,9,22]],"date-time":"2010-09-22T13:22:10Z","timestamp":1285161730000},"page":"21-30","source":"Crossref","is-referenced-by-count":36,"title":["Involvement of toll-like receptor 4 in alveolar bone loss and glucose homeostasis in experimental periodontitis"],"prefix":"10.1111","volume":"46","author":[{"given":"K.","family":"Watanabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Iizuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Adeleke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. E.","family":"Shlimon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Yasin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Horvath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. G.","family":"Unterman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,9,22]]},"reference":[{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1902\/jop.2005.76.11-S.2075","article-title":"A proposed model linking inflammaion to obesity, diabetes, and periodontal infection","volume":"76","author":"Genco","year":"2005","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/dmrr.568","article-title":"Inflammation and the etiology of type 2 diabetes","volume":"22","author":"Sjoholm","year":"2006","journal-title":"Diabetes metab Res Rev"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1600-0757.2006.00186.x","article-title":"Metabolic disorders related to obesity and periodontal disease","volume":"43","author":"Saito","year":"2007","journal-title":"Peirodontol 2000"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/154405910708600503","article-title":"Obesity, inflammation and periodontal disease","volume":"86","author":"Pischon","year":"2007","journal-title":"J Dent Res"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1053\/j.gastro.2007.03.059","article-title":"Obesity, inflammation, and insulin resistance","volume":"132","author":"Schoelson","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1902\/jop.2008.070605","article-title":"Effect of periodontitis on insulin resistance and the onset of Type 2 diabetes mellitus in Zucker Diabetic Fatty Rats","volume":"79","author":"Watanabe","year":"2008","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0021-9150(99)00265-8","article-title":"Effect of dietary fat on the development of non-insulin dependent diabetes mellitus in obese Zucker diabetic fatty male and female rats","volume":"148","author":"Corsetti","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1016\/S0006-291X(03)00821-0","article-title":"DNA microarray analysis of human gingival fibroblasts from healthy and inflammatory gingival tissues","volume":"305","author":"Wang","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.febslet.2004.05.072","article-title":"Lipopolysaccharide signaling induces serum amyloid A (SAA) synthesis in human hepatocytes in vitro","volume":"569","author":"Migita","year":"2004","journal-title":"FEBS Lett"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1159\/000086657","article-title":"TLR signaling and the function of dendritic cells","volume":"86","author":"Hemmi","year":"2005","journal-title":"Chem Immunol Allergy"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/sj.gene.6364282","article-title":"Gingival epithelial cells heterozygous for Toll-like receptor 4 polymorphism Asp299Gly ad Thr399ile are hypo-responsive to Porphyromonas gingivalis","volume":"7","author":"Kinane","year":"2006","journal-title":"Genes Immun"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00418-006-0230-1","article-title":"Presence of functional TLR2 and TLR4 on human adipocytes","volume":"127","author":"Bes-Houtmann","year":"2007","journal-title":"Histochem Cell Biol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"2595","DOI":"10.2337\/db08-0038","article-title":"Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects","volume":"57","author":"Reyna","year":"2008","journal-title":"Diabetes"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1574-695X.2008.00386.x","article-title":"Toll-like receptor 4 singaling plays a role in triggering periodontal infection","volume":"52","author":"Sun","year":"2008","journal-title":"FEMS Immunol Med Microbiol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/ni1112","article-title":"Toll-like receptor control of the adaptive immune responses","volume":"5","author":"Iwasaki","year":"2004","journal-title":"Nat Immunol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1399-302X.2007.00335.x","article-title":"Activation of toll-like receptors 2 and 4 by gram-negative periodontal bacteria","volume":"22","author":"Kikkert","year":"2007","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1365-2249.2007.03346.x","article-title":"Toll-like receptor 4-dependent recognition of structurally different forms of chemically synthesized lipid As of Porphyromonas gingivalis","volume":"148","author":"Sawada","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1399-302X.2007.00410.x","article-title":"Lack of Toll-Like Receptro 4 decreases lipopolysaccharides-induced bone resorption in C3H\/HeJ mice in vivo","volume":"23","author":"Nakamura","year":"2008","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.4049\/jimmunol.174.9.5390","article-title":"Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4","volume":"174","author":"Weatherill","year":"2005","journal-title":"J Immunol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1172\/JCI28898","article-title":"TLR4 links innate immunity and fatty acid-induced insulin resistance","volume":"116","author":"Shi","year":"2006","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"35279","DOI":"10.1074\/jbc.M706762200","article-title":"A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-Like Receptors 2 and 4 and JNK-dependent pathways","volume":"282","author":"Nguyen","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.2337\/db06-1595","article-title":"Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance","volume":"56","author":"Tsukumo","year":"2007","journal-title":"Diabetes"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.bbrc.2006.05.170","article-title":"Activation of Toll-like receptor 4 is associated with insulin resistance in adipocytes","volume":"346","author":"Song","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1172\/JCI117936","article-title":"Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance","volume":"95","author":"Hotamisligil","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentarions in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1902\/jop.2000.71.9.1395","article-title":"HLA-B27 transgenic rats are susceptible to accelerated alveolar bone loss","volume":"71","author":"Tatakis","year":"2000","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB27|cit27","first-page":"18.60","volume-title":"Molecular Cloning","author":"Sambrook","year":"1989"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"15985","DOI":"10.1074\/jbc.275.21.15985","article-title":"SOCS-3 is an insulin-induced negative regulator of insulin signaling","volume":"275","author":"Emanuelli","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.2337\/diabetes.51.12.3391","article-title":"Inerleukin-6 induces cellular insulin resistance in hepatocytes","volume":"51","author":"Senn","year":"2002","journal-title":"Diabetes"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"5434","DOI":"10.1128\/MCB.24.12.5434-5446.2004","article-title":"Suppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanisms","volume":"24","author":"Ueki","year":"2004","journal-title":"Mol Cell Biol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1161\/CIRCRESAHA.106.142851","article-title":"Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity","volume":"100","author":"Kim","year":"2007","journal-title":"Circ Res"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.162.7.3749","article-title":"Cutting Edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharides: evidence for TLR4 as the Lps gene product","volume":"162","author":"Hoshino","year":"1999","journal-title":"J Immunol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1902\/jop.2009.080393","article-title":"Ability of supragingival plaque to induce toll-like receptor 4-mediated stimulation is associated with cytokine production by peripheral blood mononuclear cells","volume":"80","author":"Yamaguchi","year":"2009","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"8296","DOI":"10.4049\/jimmunol.177.12.8296","article-title":"Cutting Edge: TLR2 is required for the innate response to Prophyromonas gingivalis activation leads to bacterial persistence and TLR2 deficiency attenuates induced alveolar bone resorption","volume":"177","author":"Burns","year":"2006","journal-title":"J Immunol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1902\/jop.1980.51.1.6","article-title":"Conditions and pathological features of rapidly destructive, experimental periodontitis in dogs","volume":"51","author":"Schroeder","year":"1980","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1177\/00220345820610071001","article-title":"The effect of supragingival plaque control on the composition of the subgingival microbial flora in ligature-induced periodontitis in the monkey","volume":"61","author":"Siegrist","year":"1982","journal-title":"J Dent Res"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1902\/jop.2006.050184","article-title":"Periodontitis deteriorates metabolic control in Type 2 Diabetic Goto-Kakizaki rats","volume":"77","author":"Pontes Andersen","year":"2006","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1128\/JB.183.12.3770-3783.2001","article-title":"Bacterial diversity in human subgingival plaque","volume":"183","author":"Paster","year":"2001","journal-title":"J Bacteriol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.4049\/jimmunol.165.7.3541","article-title":"Lipopolysaccharide induces physical proximity between CD14 and toll-like receptor 4 (TLR4) prior to nuclear translocation of NF-kappa B","volume":"165","author":"Jiang","year":"2000","journal-title":"J Immunol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"35489","DOI":"10.1074\/jbc.M201366200","article-title":"Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers","volume":"277","author":"Flo","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"R1412","DOI":"10.1186\/ar1840","article-title":"Between adaptive and innate immunity: TLR4-mediated perforin production by CD28null T-helper cells in ankylosing spondylitis","volume":"7","author":"Raffeiner","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB42|cit42","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1016\/j.molimm.2007.10.008","article-title":"TLR4 signaling induces functional nerve growth factor receptor p75NTR on mouse dendritic cells via p38MAPK and NF-kappa B pathways","volume":"45","author":"Jiang","year":"2008","journal-title":"Mol Immunol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB43|cit43","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.imlet.2009.05.006","article-title":"Partial role of TLR4 as a receptor responding to damage-associated molecular pattern","volume":"125","author":"Lee","year":"2009","journal-title":"Immunol Lett"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB44|cit44","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1902\/jop.2000.71.7.1167","article-title":"Induction of experimental periodontitis in mice with Phophyromonas gingivalis-adhered ligatures","volume":"71","author":"Kimura","year":"2000","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB45|cit45","doi-asserted-by":"crossref","first-page":"20466","DOI":"10.1073\/pnas.0710335105","article-title":"Diet-induced obesity in mice causes changes in imuune responses and bone loss manifested by bacterial challenge","volume":"104","author":"Amar","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB46|cit46","doi-asserted-by":"crossref","first-page":"E681","DOI":"10.1152\/ajpendo.90931.2008","article-title":"High doses of dexamethasone induce increased \u03b2-cell proliferation in pancreatic rat islets","volume":"21","author":"Rafacho","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB47|cit47","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1046\/j.1365-2249.2003.02211.x","article-title":"Evidence of expression of endotoxin receptors CD14, toll-like receptors TLR4 and TLR2 and associated molecule MD-2 and of sensitivity to endotoxin (LPS) in islet beta cells","volume":"133","author":"Vives-PI","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB48|cit48","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1016\/j.molimm.2006.11.019","article-title":"17\u03b2-Estradiol downregulates Kupffer cell TLR4-dependent p38MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage","volume":"44","author":"Hsieh","year":"2007","journal-title":"Mol Immunol"},{"key":"10.1111\/j.1600-0765.2010.01304.x-BIB49|cit49","doi-asserted-by":"crossref","first-page":"R1262","DOI":"10.1152\/ajpregu.00724.2005","article-title":"Kupffer cell-generated PGE2 triggers the febrile response of guinea pigs to intravenously injected LPS","volume":"290","author":"Li","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0765.2010.01304.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1600-0765.2010.01304.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T12:41:09Z","timestamp":1685796069000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0765.2010.01304.x"}},"subtitle":["Periodontitis, TLR4 and glucose homeostasis"],"short-title":[],"issued":{"date-parts":[[2010,9,22]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1600-0765.2010.01304.x","relation":{},"ISSN":["0022-3484"],"issn-type":[{"value":"0022-3484","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9,22]]}}}