{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:28:38Z","timestamp":1788870518937,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1838,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1111\/j.1600-0765.2010.01310.x","type":"journal-article","created":{"date-parts":[[2010,8,22]],"date-time":"2010-08-22T06:36:55Z","timestamp":1282459015000},"page":"58-66","source":"Crossref","is-referenced-by-count":42,"title":["Reduced expression of lipopolysaccharide-induced CXC chemokine in Porphyromonas gingivalis-induced experimental periodontitis in matrix metalloproteinase-8 null mice"],"prefix":"10.1111","volume":"46","author":[{"given":"M.","family":"Hern\u00e1ndez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Gamonal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Salo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Tervahartiala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hukkanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Tj\u00e4derhane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Sorsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2010,8,20]]},"reference":[{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB1|cit1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/07853890600800103","article-title":"Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation","volume":"38","author":"Sorsa","year":"2006","journal-title":"Ann Med"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1034\/j.1600-051X.2002.291107.x","article-title":"Porphyromonas gingivalis, Bacteroides forsythus and other putative periodontal pathogens in subjects with and without periodontal destruction","volume":"29","author":"van Winkelhoff","year":"2002","journal-title":"J Clin Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1902\/jop.1993.64.5.474","article-title":"Role of matrix metalloproteinases in human periodontal diseases","volume":"64","author":"Birkedal-Hansen","year":"1993","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1902\/jop.2004.75.1.106","article-title":"The effect of adjunctive low-dose doxycycline therapy on clinical parameters and gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitis","volume":"75","author":"Emingil","year":"2004","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1034\/j.1600-051x.2002.290308.x","article-title":"Collagenase-2 (MMP-8) and collagenase-3 (MMP-13) in adult periodontitis: molecular forms and levels in gingival crevicular fluid and immunolocalisation in gingival tissue","volume":"29","author":"Kiili","year":"2002","journal-title":"J Clin Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1034\/j.1600-0765.2003.00663.x","article-title":"Changes in gingival crevicular fluid matrix metalloproteinase-8 levels during periodontal treatment and maintenance","volume":"38","author":"Kinane","year":"2003","journal-title":"J Periodontal Res"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1034\/j.1600-0765.2003.00677.x","article-title":"Gingival crevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis","volume":"38","author":"Mantyla","year":"2003","journal-title":"J Periodontal Res"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1601-0825.2009.01603.x","article-title":"Detection of gingival crevicular fluid MMP-8 levels with different laboratory and chair-side methods","volume":"16","author":"Sorsa","year":"2009","journal-title":"Oral Dis"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1601-0825.2004.01038.x","article-title":"Matrix metalloproteinases (MMPs) in oral diseases","volume":"10","author":"Sorsa","year":"2004","journal-title":"Oral Dis"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"7642","DOI":"10.4049\/jimmunol.175.11.7642","article-title":"Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis","volume":"175","author":"Van Lint","year":"2005","journal-title":"J Immunol"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"e312","DOI":"10.1371\/journal.pone.0000312","article-title":"LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity","volume":"2","author":"Tester","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yexcr.2008.10.015","article-title":"Tamoxifen decreases extracellular TGF-beta1 secreted from breast cancer cells--a post-translational regulation involving matrix metalloproteinase activity","volume":"315","author":"Nilsson","year":"2009","journal-title":"Exp Cell Res"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1096\/fj.06-7860com","article-title":"Increased inflammation delays wound healing in mice deficient in collagenase-2 (MMP-8)","volume":"21","author":"Gutierrez-Fernandez","year":"2007","journal-title":"FASEB J"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1600-0722.2009.00620.x","article-title":"Healing of extraction sockets in collagenase-2 (matrix metalloproteinase-8)-deficient mice","volume":"117","author":"Korpi","year":"2009","journal-title":"Eur J Oral Sci"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/ng1249","article-title":"Loss of collagenase-2 confers increased skin tumor susceptibility to male mice","volume":"35","author":"Balbin","year":"2003","journal-title":"Nat Genet"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1128\/IAI.00873-08","article-title":"Local and systemic responses in matrix metalloproteinase 8-deficient mice during Porphyromonas gingivalis-induced periodontitis","volume":"77","author":"Kuula","year":"2009","journal-title":"Infect Immun"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1600-0765.2008.01134.x","article-title":"Granulocyte chemotactic protein 2 (gcp-2\/cxcl6) complements interleukin-8 in periodontal disease","volume":"44","author":"Kebschull","year":"2009","journal-title":"J Periodontal Res"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1600-0757.1997.tb00191.x","article-title":"The host response to the microbial challenge in periodontitis: assembling the players","volume":"14","author":"Kornman","year":"1997","journal-title":"Periodontol 2000"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1189\/jlb.0204065","article-title":"Interleukin-17 regulates expression of the CXC chemokine LIX\/CXCL5 in osteoblasts: implications for inflammation and neutrophil recruitment","volume":"76","author":"Ruddy","year":"2004","journal-title":"J Leukoc Biol"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1902\/jop.2008.070514","article-title":"Stromal-derived factor-1alpha (CXCL12) levels increase in periodontal disease","volume":"79","author":"Havens","year":"2008","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.bone.2005.01.021","article-title":"Stromal cell-derived factor-1 binding to its chemokine receptor CXCR4 on precursor cells promotes the chemotactic recruitment, development and survival of human osteoclasts","volume":"36","author":"Wright","year":"2005","journal-title":"Bone"},{"issue":"Suppl 1","key":"10.1111\/j.1600-0765.2010.01310.x-BIB22|cit22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/03008200390152133","article-title":"SDF-1 increases recruitment of osteoclast precursors by upregulation of matrix metalloproteinase-9 activity","volume":"44","author":"Yu","year":"2003","journal-title":"Connect Tissue Res"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB23|cit23","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1038\/sj.bjc.6600858","article-title":"Role of RANKL-induced osteoclast formation and MMP-dependent matrix degradation in bone destruction by breast cancer metastasis","volume":"88","author":"Ohshiba","year":"2003","journal-title":"Br J Cancer"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/sj.bjc.6604239","article-title":"Collagenase-2 (matrix metalloproteinase-8) plays a protective role in tongue cancer","volume":"98","author":"Korpi","year":"2008","journal-title":"Br J Cancer"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"3980","DOI":"10.4049\/jimmunol.175.6.3980","article-title":"An immune response directed to proteinase and adhesin functional epitopes protects against Porphyromonas gingivalis-induced periodontal bone loss","volume":"175","author":"O\u2019Brien-Simpson","year":"2005","journal-title":"J Immunol"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1128\/IAI.66.9.4158-4162.1998","article-title":"Bone resorption caused by three periodontal pathogens in vivo in mice is mediated in part by prostaglandin","volume":"66","author":"Zubery","year":"1998","journal-title":"Infect Immun"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/j.1365-2249.2005.02852.x","article-title":"CXCL12 and CXCR4 expression by human gingival fibroblasts in periodontal disease","volume":"141","author":"Hosokawa","year":"2005","journal-title":"Clin Exp Immunol"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1177\/00220345940730080201","article-title":"Matrix metalloproteinases (MMP-2 and MMP-9) of the oral cavity: cellular origin and relationship to periodontal status","volume":"73","author":"Makela","year":"1994","journal-title":"J Dent Res"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB29|cit29","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1177\/00220345000790120801","article-title":"The in vivo expression of the collagenolytic matrix metalloproteinases (MMP-2, -8, -13, and -14) and matrilysin (MMP-7) in adult and localized juvenile periodontitis","volume":"79","author":"Tervahartiala","year":"2000","journal-title":"J Dent Res"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1034\/j.1600-0757.2003.03106.x","article-title":"Proteolytic host cell enzymes in gingival crevice fluid","volume":"31","author":"Uitto","year":"2003","journal-title":"Periodontol 2000"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1600-0765.1988.tb01618.x","article-title":"Comparison of interstitial collagenases from human gingiva, sulcular fluid and polymorphonuclear leukocytes","volume":"23","author":"Sorsa","year":"1988","journal-title":"J Periodontal Res"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"144","DOI":"10.2353\/ajpath.2008.080081","article-title":"Matrix metalloproteinase-8 facilitates neutrophil migration through the corneal stromal matrix by collagen degradation and production of the chemotactic peptide Pro-Gly-Pro","volume":"173","author":"Lin","year":"2008","journal-title":"Am J Pathol"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1046\/j.1432-1033.2003.03760.x","article-title":"Gelatinase B\/MMP-9 and neutrophil collagenase\/MMP-8 process the chemokines human GCP-2\/CXCL6, ENA-78\/CXCL5 and mouse GCP-2\/LIX and modulate their physiological activities","volume":"270","author":"Van Den Steen","year":"2003","journal-title":"Eur J Biochem"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S1286-4579(00)01272-7","article-title":"The role of immune responses in bone loss during periodontal disease","volume":"2","author":"Baker","year":"2000","journal-title":"Microbes Infect"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1042\/CS20060274","article-title":"Regulation and enzymatic basis of bone resorption by human osteoclasts","volume":"112","author":"Fuller","year":"2007","journal-title":"Clin Sci (Lond)"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB36|cit36","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1902\/jop.2007.060398","article-title":"RANKL upregulation associated with periodontitis and Porphyromonas gingivalis","volume":"78","author":"Wara-aswapati","year":"2007","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.1600-051X.2009.01390.x","article-title":"Over-expression of forkhead box P3 and its association with receptor activator of nuclear factor-kappa B ligand, interleukin (IL) -17, IL-10 and transforming growth factor-beta during the progression of chronic periodontitis","volume":"36","author":"Dutzan","year":"2009","journal-title":"J Clin Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB38|cit38","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1902\/jop.2004.75.12.1586","article-title":"Levels of cytokine receptor activator of nuclear factor kappaB ligand in gingival crevicular fluid in untreated chronic periodontitis patients","volume":"75","author":"Vernal","year":"2004","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB39|cit39","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1902\/jop.2006.050376","article-title":"High expression levels of receptor activator of nuclear factor-kappa B ligand associated with human chronic periodontitis are mainly secreted by CD4\u2003+\u2003 T lymphocytes","volume":"77","author":"Vernal","year":"2006","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1600-051X.2008.01314.x","article-title":"Free soluble receptor activator of nuclear factor-kappab ligand in gingival crevicular fluid correlates with distinct pathogens in periodontitis patients","volume":"35","author":"Sakellari","year":"2008","journal-title":"J Clin Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB41|cit41","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1177\/154405910408300216","article-title":"Differential expression of RANKL and osteoprotegerin in gingival crevicular fluid of patients with periodontitis","volume":"83","author":"Mogi","year":"2004","journal-title":"J Dent Res"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB42|cit42","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/j.micinf.2008.08.007","article-title":"Porphyromonas gingivalis regulates the RANKL-OPG system in bone marrow stromal cells","volume":"10","author":"Reddi","year":"2008","journal-title":"Microbes Infect"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB43|cit43","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1600-051X.2007.01061.x","article-title":"Gingival crevicular fluid levels of RANKL and OPG in periodontal diseases: implications of their relative ratio","volume":"34","author":"Bostanci","year":"2007","journal-title":"J Clin Periodontol"},{"key":"10.1111\/j.1600-0765.2010.01310.x-BIB44|cit44","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1128\/IAI.70.6.3143-3148.2002","article-title":"Bacteria induce osteoclastogenesis via an osteoblast-independent pathway","volume":"70","author":"Jiang","year":"2002","journal-title":"Infect Immun"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0765.2010.01310.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1600-0765.2010.01310.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,7]],"date-time":"2021-02-07T18:50:49Z","timestamp":1612723849000},"score":1,"resource":{"primary":{"URL":"http:\/\/doi.wiley.com\/10.1111\/j.1600-0765.2010.01310.x"}},"subtitle":["LIX\/CXCL5 in periodontitis MMP-8\u2212\/\u2212 mice model"],"short-title":[],"issued":{"date-parts":[[2010,8,20]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,2]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1600-0765.2010.01310.x","relation":{},"ISSN":["0022-3484"],"issn-type":[{"value":"0022-3484","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8,20]]}}}