{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,20]],"date-time":"2025-07-20T22:53:38Z","timestamp":1753052018029},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":1653,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1111\/j.1600-0765.2011.01344.x","type":"journal-article","created":{"date-parts":[[2011,2,22]],"date-time":"2011-02-22T03:21:43Z","timestamp":1298344903000},"page":"310-317","source":"Crossref","is-referenced-by-count":11,"title":["Analysis of genotypic variation in genes associated with virulence in Aggregatibacter actinomycetemcomitans clinical isolates"],"prefix":"10.1111","volume":"46","author":[{"given":"E. T.","family":"Pinheiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ota-Tsuzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. R. S.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. C. R.","family":"Nunes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. L.","family":"Longo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wikstrom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. P. A.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,2,21]]},"reference":[{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB1|cit1","first-page":"121","article-title":"Update on Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis in human periodontal disease","volume":"1","author":"Slots","year":"1999","journal-title":"J Int Acad Periodontol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB2|cit2","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1600-0757.2006.00189.x","article-title":"How we got attached to Actinobacillus actinomycetemcomitans: a model for infectious diseases","volume":"42","author":"Fine","year":"2006","journal-title":"Periodontol 2000"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB3|cit3","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1128\/JCM.34.6.1576-1578.1996","article-title":"Highly toxic clone of Actinobacillus actinomycetemcomitans in geographically widespread cases of juvenile periodontitis in adolescents of African origin","volume":"34","author":"Haubek","year":"1996","journal-title":"J Clin Microbiol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB4|cit4","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1902\/jop.1998.69.9.998","article-title":"Relationship between conversion of localized juvenile periodontitis - susceptible children from health to disease and Actinobacillus actinomycetemcomitans leukotoxin promoter structure","volume":"69","author":"Bueno","year":"1998","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB5|cit5","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1177\/154405910408301006","article-title":"The highly leukotoxic JP2 clone of Actinobacillus actinomycetemcomitans and progression of periodontal attachment loss","volume":"83","author":"Haubek","year":"2004","journal-title":"J Dent Res"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB6|cit6","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1128\/JCM.33.2.395-401.1995","article-title":"Evidence for absence in northern Europe of especially virulent clonal types of Actinobacillus actinomycetemcomitans","volume":"33","author":"Haubek","year":"1995","journal-title":"J Clin Microbiol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB7|cit7","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1099\/13500872-140-8-2049","article-title":"Population structure of Actinobacillus actinomycetemcomitans: a framework for studies of disease-associated properties","volume":"140","author":"Poulsen","year":"1994","journal-title":"Microbiology"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB8|cit8","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1128\/IAI.01734-06","article-title":"Microevolution and patterns of dissemination of the JP2 clone of Aggregatibacter (Actinobacillus) actinomycetemcomitans","volume":"75","author":"Haubek","year":"2007","journal-title":"Infect Immun"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB9|cit9","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1006\/anae.1998.0158","article-title":"ApaH polymorphism in clinical Actinobacillus actinomycetemcomitans isolates","volume":"4","author":"Saarela","year":"1998","journal-title":"Anaerobe"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB10|cit10","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1128\/JCM.40.4.1181-1187.2002","article-title":"Population structure and genetic diversity of Actinobacillus actinomycetemcomitans strains isolated from localized juvenile periodontitis patients","volume":"40","author":"Kaplan","year":"2002","journal-title":"J Clin Microbiol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB11|cit11","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1099\/mic.0.2007\/005892-0","article-title":"Molecular heterogeneity of EmaA, an oligomeric autotransporter adhesin of Aggregatibacter (Actinobacillus) actinomycetemcomitans","volume":"153","author":"Tang","year":"2007","journal-title":"Microbiology"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB12|cit12","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1399-302X.2009.00547.x","article-title":"Genetic diversity and toxic activity of Aggregatibacter actinomycetemcomitans isolates","volume":"24","author":"Kawamoto","year":"2009","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB13|cit13","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1128\/IAI.71.5.2384-2393.2003","article-title":"Aae, an autotransporter involved in adhesion of Actinobacillus actinomycetemcomitans to epithelial cells","volume":"71","author":"Rose","year":"2003","journal-title":"Infect Immun"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB14|cit14","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1046\/j.1365-2958.2003.03748.x","article-title":"Outer membrane protein 100 a versatile virulence factor of Actinobacillus Actinomycetemcomitans","volume":"50","author":"Asakawa","year":"2003","journal-title":"Mol Microbiol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB15|cit15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/08959374950090011001","article-title":"Characteristics of Actinobacillus actinomycetemcomitans invasion of and adhesion to cultured epithelial cells","volume":"9","author":"Fives-Taylor","year":"1995","journal-title":"Adv Dent Res"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB16|cit16","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1902\/jop.2008.080254","article-title":"Persistence of extracrevicular bacterial reservoirs after treatment of aggressive periodontitis","volume":"79","author":"Johnson","year":"2008","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB17|cit17","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1046\/j.0902-0055.2003.00102.x","article-title":"Two epithelial cell invasion-related loci of the oral pathogen Actinobacillus actinomycetemcomitans","volume":"19","author":"Li","year":"2004","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB18|cit18","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1074\/jbc.274.3.1203","article-title":"The gene ialA, associated with the invasion of human erythrocytes by Bartonella bacilliformis, designates a nudix hydrolase active on dinucleoside 5\u2032-polyphosphates","volume":"15","author":"Conyers","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB19|cit19","doi-asserted-by":"crossref","first-page":"37834","DOI":"10.1074\/jbc.M107032200","article-title":"The gene ygdP, associated with the invasiveness of Escherichia coli K1, designates a Nudix hydrolase, Orf176, active on adenosine (5\u2032)-pentaphospho-(5\u2032)-adenosine (Ap5A)","volume":"12","author":"Bessman","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB20|cit20","doi-asserted-by":"crossref","first-page":"32602","DOI":"10.1074\/jbc.M305994200","article-title":"Regulation of dinucleoside poliphosphate pools by the ygdp and apah hydrolases is essential for the ability of Salmonella enterica serovar typhimurium to invade cultured mammalian cells","volume":"278","author":"Ismail","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB21|cit21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1074\/mcp.M100030-MCP200","article-title":"The Rickettsia prowazekii invasion gene homolog (inv A) encodes a nudix hydrolase active on adenosine (5\u2032)-pentaphospho-(5\u2032)-adenosine","volume":"1","author":"Gaywee","year":"2002","journal-title":"Mol Cell Proteomics"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB22|cit22","first-page":"1225","article-title":"The Actinobacillus actinomycetemcomitans apaH gene is implicated in invasion of epithelial cells","volume":"78","author":"Saarela","year":"1999","journal-title":"J Dent Res"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB23|cit23","first-page":"659","article-title":"Prevalence of bone loss and detection of Actinobacillus actinomycetemcomitans in Brazilian schoolchildren","volume":"75","author":"Brunetti","year":"1996","journal-title":"J Dent Res"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB24|cit24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1600-051X.1989.tb01660.x","article-title":"Black-pigmented bacteroides species and Actinobacillus actinomycetemcomitans in subgingival plaque of adult Kenyans","volume":"16","author":"Dahl\u00e9n","year":"1989","journal-title":"J Clin Periodontol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB25|cit25","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1600-051X.1992.tb02174.x","article-title":"The effect of supragingival plaque control on the subgingival microbiota in subjects with periodontal disease","volume":"19","author":"Dahl\u00e9n","year":"1992","journal-title":"J Clin Periodontol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB26|cit26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1399-302X.2006.00285.x","article-title":"Phenotypic and genotypic identification of enterococci isolated from canals of root-filled teeth with periapical lesions","volume":"21","author":"Pinheiro","year":"2006","journal-title":"Oral Microbiol Immunol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB27|cit27","doi-asserted-by":"crossref","first-page":"3371","DOI":"10.1099\/mic.0.28193-0","article-title":"Intragenomic recombination in the highly leukotoxic JP2 clone of Actinobacillus actinomycetemcomitans","volume":"151","author":"Eriksen","year":"2005","journal-title":"Microbiology"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB28|cit28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/B978-044450740-2\/50008-3","volume-title":"New Approaches for the Generation and Analysis of Microbial Typing Data","author":"Struelens","year":"2001"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB29|cit29","first-page":"2.1","volume-title":"Short Protocols in Molecular Biology","author":"Ausubel","year":"1999"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB30|cit30","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1902\/jop.1996.67.3s.282","article-title":"The microbiology of early-onset periodontitis: association of highly toxic Actinobacillus actinomycetemcomitans strains with localized juvenile periodontitis","volume":"67","author":"Zambon","year":"1996","journal-title":"J Periodontol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB31|cit31","doi-asserted-by":"crossref","first-page":"5375","DOI":"10.1128\/IAI.69.9.5375-5384.2001","article-title":"Structural and genetic analyses of O polysaccharide from Actinobacillus actinomycetemcomitans serotype","volume":"69","author":"Kaplan","year":"2001","journal-title":"Infect Immun"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB32|cit32","doi-asserted-by":"crossref","first-page":"7378","DOI":"10.1128\/JB.01203-09","article-title":"Genome sequence of Aggregatibacter actinomycetemcomitans serotype c strain D11S-1","volume":"191","author":"Chen","year":"2009","journal-title":"J Bacteriol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB33|cit33","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1128\/JB.00157-10","article-title":"Genome sequence of naturally competent Aggregatibacter actinomycetemcomitans serotype a strain D7S-1","volume":"192","author":"Chen","year":"2010","journal-title":"J Bacteriol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB34|cit34","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1111\/j.1600-0722.1997.tb00246.x","article-title":"Relationship of serotype, leukotoxin gene type and lysogeny in Actinobacillus actinomycetemcomitans to periodontal disease status","volume":"105","author":"Tinoco","year":"1997","journal-title":"Eur J Oral Sci"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB35|cit35","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1139\/W05-121","article-title":"Actinobacillus actinomycetemcomitans serotype specific genotypes and periodontal status in Brazilian subjects","volume":"52","author":"Teixeira","year":"2006","journal-title":"Can J Microbiol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB36|cit36","first-page":"471","article-title":"Immune response to cytolethal distending toxin of Aggregatibacter actinomycetemcomitans in periodontitis patients","volume":"45","author":"Ando","year":"2010","journal-title":"J Periodontal Res"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB37|cit37","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.2041-1014.2010.00567.x","article-title":"Occurrence of Aggregatibacter actinomycetemcomitans serotypes in subgingival plaque from United States subjects","volume":"25","author":"Chen","year":"2010","journal-title":"Mol Oral Microbiol"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB38|cit38","unstructured":"Yue G Kaplan JB Fine DH A motif in aae mediates binding to BECS and endothelium"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB39|cit39","first-page":"1","article-title":"The etiology of periodontal disease revisited by population genetic analysis","volume":"41","author":"Kilian","year":"2006","journal-title":"Periodontol 2000"},{"key":"10.1111\/j.1600-0765.2011.01344.x-BIB40|cit40","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.1099\/00221287-148-12-3993","article-title":"Differences in iron acquisition from human haemoglobin among strains of Actinobacillus actinomycetemcomitans","volume":"148","author":"Hayashida","year":"2002","journal-title":"Microbiology"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0765.2011.01344.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/onlinelibrary.wiley.com\/wol1\/doi\/10.1111\/j.1600-0765.2011.01344.x\/fullpdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,19]],"date-time":"2021-11-19T08:04:30Z","timestamp":1637309070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0765.2011.01344.x"}},"subtitle":["A.\u00a0actinomycetemcomitans genotypes"],"short-title":[],"issued":{"date-parts":[[2011,2,21]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,6]]}},"URL":"https:\/\/doi.org\/10.1111\/j.1600-0765.2011.01344.x","relation":{},"ISSN":["0022-3484"],"issn-type":[{"value":"0022-3484","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2,21]]}}}