{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T07:59:32Z","timestamp":1770883172811,"version":"3.50.1"},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T00:00:00Z","timestamp":1312243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p><jats:italic>Santos VR, Ribeiro FV, Lima JA, Miranda TS, Feres M, Bastos MF, Duarte PM. Partial\u2010 and full\u2010mouth scaling and root planing in type 2 diabetic subjects: a 12\u2010mo follow\u2010up of clinical parameters and levels of cytokines and osteoclastogenesis\u2010related factors. J Periodont Res 2012; 47: 45\u201354. \u00a9 2011 John Wiley &amp; Sons A\/S<\/jats:italic><\/jats:p><jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> The aim of this study was to evaluate the effects of full\u2010mouth scaling and root planing (FMSRP) and partial\u2010mouth scaling and root planing (PMSRP), up to 12\u2003mo after treatment, on clinical parameters, and levels of cytokines and osteoclastogenesis\u2010related factors in type 2 diabetic subjects with chronic periodontitis.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Thirty\u2010four subjects received FMSRP (<jats:italic>n<\/jats:italic>\u2003=\u200317) or PMSRP (<jats:italic>n<\/jats:italic>\u2003=\u200317) within 24\u2003h or in multiple sessions, respectively. Clinical parameters and local levels of tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), interferon\u2010\u03b3 (IFN\u2010\u03b3), interleukin (IL)\u201017, IL\u201023, IL\u20104, receptor activator of NF\u2010\u03b2 ligand and osteoprotegerin were assessed at baseline, and 3, 6 and 12\u2003mo after therapies.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Clinical parameters improved after both therapies (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.05), and no between\u2010group differences were observed at any time\u2010point (<jats:italic>p<\/jats:italic>\u2003&gt;\u20030.05). Overall, there were no considerable differences in the local levels of the biomarkers studied between groups (<jats:italic>p<\/jats:italic>\u2003&gt;\u20030.05). The IL\u201023 concentration and total amount of IFN\u2010\u03b3 increased in the FMSRP group and decreased in the PMSRP group from baseline to 3\u2003mo and from baseline to 6\u2003mo, respectively (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Both PMSRP and FMSRP promoted benefits in clinical parameters and showed a similar modulation of cytokines and osteoclastogenesis\u2010related factors at 12\u2003mo in type 2 diabetic subjects.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2011.01403.x","type":"journal-article","created":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T04:04:36Z","timestamp":1312257876000},"page":"45-54","source":"Crossref","is-referenced-by-count":26,"title":["Partial\u2010 and full\u2010mouth scaling and root planing in type 2 diabetic subjects: a 12\u2010mo follow\u2010up of clinical parameters and levels of cytokines and osteoclastogenesis\u2010related factors"],"prefix":"10.1111","volume":"47","author":[{"given":"V. 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