{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:42:43Z","timestamp":1760888563186},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,9,19]],"date-time":"2011-09-19T00:00:00Z","timestamp":1316390400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2012,4]]},"abstract":"<jats:p><jats:italic>Kasuyama K, Tomofuji T, Ekuni D, Azuma T, Irie K, Endo Y, Morita M. Effects of topical application of inorganic polyphosphate on tissue remodeling in rat inflamed gingiva. J Periodont Res 2012; 47: 159\u2013164. \u00a9 2011 John Wiley &amp; Sons A\/S<\/jats:italic><\/jats:p><jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Inorganic polyphosphate [poly(P)] is a biopolymer found in almost all cells and tissues, and which promotes tissue remodeling. However, there is limited information on how poly(P) affects the connective tissue in inflamed gingiva. This study examined the effects of topical application of poly(P) on gingival connective tissue and its remodeling in a rat periodontitis model.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Male Wistar rats (<jats:italic>n\u2003<\/jats:italic>=\u200336, 8\u2003wk of age) were used in this 6\u2010wk study. The rats were divided into six groups of six rats each. The control group received no treatment. In the other groups, periodontitis was ligature\u2010induced for 4\u2003wk. After 4\u2003wk, the rats with periodontitis were further divided into five groups, and were left untreated (periodontitis group) or subjected to topical application of oral rinses containing 0, 0.1, 1 or 5% poly(P) for 2\u2003wk.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The periodontitis and 0% poly(P) groups showed a higher density of polymorphonuclear leukocytes and a lower density of collagen in gingival tissue than the control group (<jats:italic>p\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05). In contrast, groups treated with more than 1% poly(P) exhibited a lower density of polymorphonuclear leukocytes (<jats:italic>p\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05) and a higher density of collagen than the periodontitis and 0% poly(P) groups (<jats:italic>p\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05). A higher expression of fibroblast growth factor\u20102 was observed in the gingiva of rats treated with 1% poly(P) than in those treated with 0% poly(P) (<jats:italic>p\u2003<\/jats:italic>&lt;<jats:italic>\u2003<\/jats:italic>0.05).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Topical application of poly(P) may induce connective tissue remodeling, contributing to improvement of inflamed gingiva in rats.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2011.01414.x","type":"journal-article","created":{"date-parts":[[2011,9,19]],"date-time":"2011-09-19T07:44:06Z","timestamp":1316418246000},"page":"159-164","source":"Crossref","is-referenced-by-count":9,"title":["Effects of topical application of inorganic polyphosphate on tissue remodeling in rat inflamed 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