{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:08:50Z","timestamp":1791644930550,"version":"4.3.4"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,9,30]],"date-time":"2011-09-30T00:00:00Z","timestamp":1317340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:p><jats:italic>Kraft\u2010Neum\u00e4rker M, Lorenz K, Koch R, Hoffmann T, M\u00e4ntyl\u00e4 P, Sorsa T, Netuschil L. Full\u2010mouth profile of active MMP\u20108 in periodontitis patients. J Periodont Res 2012; 47: 121\u2013128. \u00a9 2011 John Wiley &amp; Sons A\/S<\/jats:italic><\/jats:p><jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> MMP\u20108 in gingival crevicular fluid is considered as a protease with high destructive potential because of its ability to degrade collagen in periodontitis\u2010affected patients. The aim of this study was to investigate whether there was a relationship between clinical diagnostic parameters and the concentration of active MMP\u20108 (aMMP\u20108) in gingival crevicular fluid in a site\u2010level full\u2010mouth analysis. Based on these data, the prognostic value of aMMP\u20108 levels in relation to pocket depth may be evaluated.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Clinical measurements of pocket depth, bleeding on probing (BOP), plaque index (PlI) and gingival index (GI), as well as samples of gingival crevicular fluid, were obtained from four sites of each tooth of nine healthy female patients with chronic generalized periodontitis. The aMMP\u20108 concentration in gingival crevicular fluid was quantified by ELISA using specific monoclonal antibodies. Multiple linear regression models for the single measures of aMMP\u20108 and pocket depth were calculated with GI and BOP as additional variables.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Between 92 and 112 recordings were obtained for each parameter in each patient. Mean values of between 31.5 and 88.8% were calculated for pocket depths of \u2265\u20034 mm. Mean pocket depths ranged from 3.11 to 4.73 mm, the mean BOP values ranged from 34.0 to 96.7% and the mean full\u2010mouth gingival crevicular fluid aMMP\u20108 concentration ranged from 3.2 to 23.7\u2003ng\/mL.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> In this sample of female periodontitis patients, a broad range of intra\u2010individual and interindividual aMMP\u20108 values was found. Although the explained variance was rather weak, a statistically significant relationship between aMMP\u20108 and pocket depth was proven.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2011.01416.x","type":"journal-article","created":{"date-parts":[[2011,9,30]],"date-time":"2011-09-30T16:28:32Z","timestamp":1317400112000},"page":"121-128","source":"Crossref","is-referenced-by-count":46,"title":["Full\u2010mouth profile of active MMP\u20108 in periodontitis 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