{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T03:49:11Z","timestamp":1775101751066,"version":"3.50.1"},"reference-count":157,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,27]],"date-time":"2011-11-27T00:00:00Z","timestamp":1322352000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p><jats:italic>Chai L, Song Y\u2010Q, Leung WK. Genetic polymorphism studies in periodontitis and Fc\u03b3 receptors. J Periodont Res 2012; 47: 273\u2013285. \u00a9 2011 John Wiley &amp; Sons A\/S<\/jats:italic><\/jats:p><jats:p>Periodontitis is a complex chronic subgingival plaque\u2010induced inflammatory disease influenced by multiple factors, including genetics, behavior and the environment. Many genetic association studies have been conducted in periodontology. One of the most extensively investigated gene families is the Fc\u03b3 receptor gene family, which plays a key role in regulating host immune responses to bacteria. Unlike other genetic polymorphisms reported in periodontology, most Fc\u03b3 receptor polymorphisms reported not only have established biological functions but are reported to associate with other autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus. There are, however, few recent reviews summarizing the association of this gene family with periodontitis. This article critically reviews the current understanding of genetic polymorphism studies in periodontitis, then summarizes the research status of Fc\u03b3 receptor polymorphisms and periodontitis and also of other genes involved in the regulatory network of Fc\u03b3 receptors, with special reference to their anticipated biological roles. Moreover, some possible future research directions in the related area are discussed.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2011.01437.x","type":"journal-article","created":{"date-parts":[[2011,11,28]],"date-time":"2011-11-28T05:26:18Z","timestamp":1322457978000},"page":"273-285","source":"Crossref","is-referenced-by-count":37,"title":["Genetic polymorphism studies in periodontitis and Fc\u03b3 receptors"],"prefix":"10.1111","volume":"47","author":[{"given":"L.","family":"Chai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.\u2010Q.","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. K.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,11,27]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00199.x"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.06.047"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2007.04.011"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2006.00688.x"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01401"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-960167"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00806.x"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.012021-0"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00164.x"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00118.x"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/19.13.3763"},{"key":"e_1_2_9_13_2","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes","volume":"72","author":"Group T","year":"1993","journal-title":"Cell"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/306234a0"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2475911"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2772657"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5281.1516"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/4482"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5343.1580"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.274.5287.536"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01626"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099870"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.6.080604.162309"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/85776"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0b013e328336eae9"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn250"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08494"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2008.07.006"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.08091354"},{"key":"e_1_2_9_30_2","first-page":"209","volume-title":"Periodontitis: Symptoms, Treatment and Prevention. Public Health in the 21st Century Series","author":"Chai L","year":"2010"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00355.x"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.123.1.119"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.171.4.1333"},{"key":"e_1_2_9_34_2","first-page":"967","article-title":"Regulation of the immune response. V. An analysis of the function of the Fc portion of antibody in suppression of an immune response with respect to interaction with components of the lymphoid system","volume":"21","author":"Chan PL","year":"1971","journal-title":"Immunology"},{"key":"e_1_2_9_35_2","doi-asserted-by":"crossref","first-page":"602","DOI":"10.4049\/jimmunol.130.2.602","article-title":"Fc\u2010dependent inhibition of mouse B cell activation by whole anti\u2010mu antibodies","volume":"130","author":"Phillips NE","year":"1983","journal-title":"J Immunol"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.139.9.3153"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.17.5430"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02114971"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.11.010"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00364238"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00218905"},{"key":"e_1_2_9_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60671-9"},{"key":"e_1_2_9_43_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.09.040191.002325"},{"key":"e_1_2_9_44_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2002.19009.x"},{"key":"e_1_2_9_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-002-0486-0"},{"key":"e_1_2_9_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2005.05.010"},{"key":"e_1_2_9_47_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2139735"},{"key":"e_1_2_9_48_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.290.5489.84"},{"key":"e_1_2_9_49_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.260705.x"},{"key":"e_1_2_9_50_2","first-page":"103","article-title":"Bacteroides\u2010specific IgG and IgA subclass antibody\u2010secreting cells isolated from chronically inflamed gingival tissues","volume":"76","author":"Ogawa T","year":"1989","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_9_51_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0039.2003.00037.x"},{"key":"e_1_2_9_52_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI110980"},{"key":"e_1_2_9_53_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200419200"},{"key":"e_1_2_9_54_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI16577"},{"key":"e_1_2_9_55_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.8.4332"},{"key":"e_1_2_9_56_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1118948"},{"key":"e_1_2_9_57_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.1.531"},{"key":"e_1_2_9_58_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.9.4572"},{"key":"e_1_2_9_59_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20011435"},{"key":"e_1_2_9_60_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-001-0294-2"},{"key":"e_1_2_9_61_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.7.2369"},{"key":"e_1_2_9_62_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114067"},{"key":"e_1_2_9_63_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118552"},{"key":"e_1_2_9_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(93)90166-I"},{"key":"e_1_2_9_65_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.172.1.19"},{"key":"e_1_2_9_66_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.147.4.1338"},{"key":"e_1_2_9_67_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI116022"},{"key":"e_1_2_9_68_2","first-page":"624","article-title":"Role of neutrophil Fc gamma RIIa (CD32) and Fc gamma RIIIb (CD16) polymorphic forms in phagocytosis of human IgG1\u2010 and IgG3\u2010opsonized bacteria and erythrocytes","volume":"83","author":"Bredius RG","year":"1994","journal-title":"Immunology"},{"key":"e_1_2_9_69_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.3.1109"},{"key":"e_1_2_9_70_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114350"},{"key":"e_1_2_9_71_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2010.01300.x"},{"key":"e_1_2_9_72_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20997"},{"key":"e_1_2_9_73_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20072413"},{"key":"e_1_2_9_74_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.123588"},{"key":"e_1_2_9_75_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04489"},{"key":"e_1_2_9_76_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-079913"},{"key":"e_1_2_9_77_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510365444"},{"key":"e_1_2_9_78_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00409.x"},{"key":"e_1_2_9_79_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1998.tb02475.x"},{"key":"e_1_2_9_80_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050305"},{"key":"e_1_2_9_81_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.5.517"},{"key":"e_1_2_9_82_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.9.1425"},{"key":"e_1_2_9_83_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.65.9.3556-3560.1997"},{"key":"e_1_2_9_84_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6363777"},{"key":"e_1_2_9_85_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00952.x"},{"key":"e_1_2_9_86_2","doi-asserted-by":"publisher","DOI":"10.1177\/00220345010800031301"},{"key":"e_1_2_9_87_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.1999.00984.x"},{"key":"e_1_2_9_88_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2006.00973.x"},{"key":"e_1_2_9_89_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2004.75.4.517"},{"key":"e_1_2_9_90_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364021"},{"key":"e_1_2_9_91_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01136.x"},{"key":"e_1_2_9_92_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090543"},{"key":"e_1_2_9_93_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2007.00701.x"},{"key":"e_1_2_9_94_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10266-008-0092-1"},{"key":"e_1_2_9_95_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2000.035002065.x"},{"key":"e_1_2_9_96_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2007.01078.x"},{"key":"e_1_2_9_97_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01530.x"},{"key":"e_1_2_9_98_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.24.7907"},{"key":"e_1_2_9_99_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.162.3.790"},{"key":"e_1_2_9_100_2","doi-asserted-by":"publisher","DOI":"10.1038\/315641a0"},{"key":"e_1_2_9_101_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1997.tb01187.x"},{"key":"e_1_2_9_102_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.2.164"},{"key":"e_1_2_9_103_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2000.71.5.723"},{"key":"e_1_2_9_104_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01298.x"},{"key":"e_1_2_9_105_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.5.2125-2130.1999"},{"key":"e_1_2_9_106_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1989.tb00859.x"},{"key":"e_1_2_9_107_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00404447"},{"key":"e_1_2_9_108_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.4.1200"},{"key":"e_1_2_9_109_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2002.290105.x"},{"key":"e_1_2_9_110_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00697.x"},{"key":"e_1_2_9_111_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.11.1554"},{"key":"e_1_2_9_112_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.2004.00499.x"},{"key":"e_1_2_9_113_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.1999.t01-1-261101.x"},{"key":"e_1_2_9_114_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1999.tb02270.x"},{"key":"e_1_2_9_115_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2001.360307.x"},{"key":"e_1_2_9_116_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00287.x"},{"key":"e_1_2_9_117_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2006.050315"},{"key":"e_1_2_9_118_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016350310006168"},{"key":"e_1_2_9_119_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.070637"},{"key":"e_1_2_9_120_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01086.x"},{"key":"e_1_2_9_121_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2009.01234.x"},{"key":"e_1_2_9_122_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-004-1157-z"},{"key":"e_1_2_9_123_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1599"},{"key":"e_1_2_9_124_2","doi-asserted-by":"crossref","first-page":"2965","DOI":"10.4049\/jimmunol.151.6.2965","article-title":"Apoptosis in splenic B lymphocytes. Regulation by protein kinase C and IL\u20104","volume":"151","author":"Illera VA","year":"1993","journal-title":"J Immunol"},{"key":"e_1_2_9_125_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.11.5704"},{"key":"e_1_2_9_126_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1521-6616(03)00145-1"},{"key":"e_1_2_9_127_2","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.4049\/jimmunol.148.11.3618","article-title":"Structure of the mouse IL\u201010 gene and chromosomal localization of the mouse and human genes","volume":"148","author":"Kim JM","year":"1992","journal-title":"J Immunol"},{"key":"e_1_2_9_128_2","doi-asserted-by":"publisher","DOI":"10.1006\/cyto.1995.1001"},{"key":"e_1_2_9_129_2","first-page":"2314","article-title":"Genetic variation in the interleukin 10 gene promoter and systemic lupus erythematosus","volume":"24","author":"Lazarus M","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_9_130_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1522"},{"key":"e_1_2_9_131_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.10274.x"},{"key":"e_1_2_9_132_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2002.290905.x"},{"key":"e_1_2_9_133_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00500.x"},{"key":"e_1_2_9_134_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028009828.x"},{"key":"e_1_2_9_135_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002510050250"},{"key":"e_1_2_9_136_2","first-page":"450","article-title":"Role of transforming growth factor beta in the pathophysiology of chronic inflammation","volume":"64","author":"Wahl SM","year":"1993","journal-title":"J Periodontol"},{"key":"e_1_2_9_137_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118107"},{"key":"e_1_2_9_138_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01570787"},{"key":"e_1_2_9_139_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00665.x"},{"key":"e_1_2_9_140_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.39.11.844"},{"key":"e_1_2_9_141_2","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.4049\/jimmunol.142.11.3857","article-title":"IL\u20104 down\u2010regulates IL\u20101 and TNF gene expression in human monocytes","volume":"142","author":"Essner R","year":"1989","journal-title":"J Immunol"},{"key":"e_1_2_9_142_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.10.3803"},{"key":"e_1_2_9_143_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00282171"},{"key":"e_1_2_9_144_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00492.x"},{"key":"e_1_2_9_145_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02976867"},{"key":"e_1_2_9_146_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2001.028005483.x"},{"key":"e_1_2_9_147_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2003.11.004"},{"key":"e_1_2_9_148_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.2003.00317.x"},{"key":"e_1_2_9_149_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10038-004-0184-x"},{"key":"e_1_2_9_150_2","doi-asserted-by":"publisher","DOI":"10.1086\/318789"},{"key":"e_1_2_9_151_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01445.x"},{"key":"e_1_2_9_152_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0923-1811(03)00149-X"},{"key":"e_1_2_9_153_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.123.3_suppl.438S"},{"key":"e_1_2_9_154_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-001-0672-4"},{"key":"e_1_2_9_155_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng749"},{"key":"e_1_2_9_156_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1992.tb01922.x"},{"key":"e_1_2_9_157_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1167728"},{"key":"e_1_2_9_158_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.291.5507.1224"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0765.2011.01437.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0765.2011.01437.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T08:40:05Z","timestamp":1698655205000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0765.2011.01437.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,27]]},"references-count":157,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1600-0765.2011.01437.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0765.2011.01437.x","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,27]]}}}