{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T18:34:47Z","timestamp":1790361287082,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2011,11,29]],"date-time":"2011-11-29T00:00:00Z","timestamp":1322524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:p><jats:italic>Al\u2010Sabbagh M, Alladah A, Lin Y, Kryscio RJ, Thomas MV, Ebersole JL, Miller CS. Bone remodeling\u2010associated salivary biomarker MIP\u20101\u03b1 distinguishes periodontal disease from health. J Periodont Res 2012; 47: 389\u2013395. \u00a9 2011 John Wiley &amp; Sons A\/S<\/jats:italic><\/jats:p><jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> The field of salivary diagnostics lacks an accepted and validated biomarker of alveolar bone remodeling. To address this, we examined levels of salivary biomolecules specifically associated with biological aspects of bone remodeling in subjects with chronic periodontitis in a case\u2013control study.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Levels of macrophage inflammatory protein\u20101\u03b1 (MIP\u20101\u03b1), osteoprotegerin, C\u2010telopeptide pyridinoline cross\u2010links of type\u2003I collagen and \u03b2\u2010C\u2010terminal type\u2003I collagen telopeptide in unstimulated whole saliva of 80 subjects (40 subjects with moderate to severe chronic periodontitis and 40 sex\u2010 and age\u2010matched healthy control subjects) were measured using enzyme immunosorbent assays. Saliva was collected before clinical examination, which included probing depth, clinical attachment loss and bleeding on probing.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The mean level of MIP\u20101\u03b1 in subjects with periodontitis was 18\u2010fold higher than in healthy subjects (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.0001). Clinical periodontal indices correlated significantly with MIP\u20101\u03b1 levels (<jats:italic>p<\/jats:italic>\u2003&lt;\u20030.0001). Of the biomolecules examined, MIP\u20101\u03b1 demonstrated the greatest ability to discriminate between periodontal disease and health as determined by the area under the curve (0.94) and classification and regression tree analysis (sensitivity 94% and specificity 92.7%). Osteoprotegerin levels were elevated 1.6\u2010fold (<jats:italic>p<\/jats:italic>\u2003=\u20030.055), whereas C\u2010telopeptide pyridinoline cross\u2010links of type\u2003I collagen and \u03b2\u2010C\u2010terminal type\u2003I collagen telopeptide levels were below the level of detection in the majority of subjects.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These findings suggest that the chemokine MIP\u20101\u03b1 may aid in identifying periodontitis. Future longitudinal studies are warranted to determine whether this biomarker can help in ascertaining the progression of bone loss in subjects with periodontal disease.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2011.01445.x","type":"journal-article","created":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T14:21:26Z","timestamp":1322749286000},"page":"389-395","source":"Crossref","is-referenced-by-count":75,"title":["Bone remodeling\u2010associated salivary biomarker MIP\u20101\u03b1 distinguishes periodontal disease from health"],"prefix":"10.1111","volume":"47","author":[{"given":"M.","family":"Al\u2010Sabbagh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Alladah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Kryscio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V.","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Ebersole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. S.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,11,29]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1996.1.1.821"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1991.tb01650.x"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1991.tb01649.x"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1991.tb02310.x"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.4s.338"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00192.x"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300104"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051x.2000.027007453.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.3.353"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1039\/b414194f"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.14219\/jada.archive.2006.0181"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607254104"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.2217\/bmm.09.68"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2008.00288.x"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01670.x"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.5650040116"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/319516a0"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.8.4231-4236.1999"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.70.7.3915-3922.2002"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.2.671"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI5703"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.145.10.3297"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910608500704"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1346.013"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2007.01.006"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2003.03108.x"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.3109\/07853899309147301"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00480-X"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/40.11.2022"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.5.859"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03256280"},{"key":"e_1_2_7_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034511399908"},{"key":"e_1_2_7_34_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080070"},{"key":"e_1_2_7_35_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080296"},{"key":"e_1_2_7_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2006.00187.x"},{"key":"e_1_2_7_37_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.034"},{"key":"e_1_2_7_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2008.01119.x"},{"key":"e_1_2_7_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2009.09.009"},{"key":"e_1_2_7_40_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01721.x"},{"key":"e_1_2_7_41_2","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_7_42_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2002.003421.x"},{"key":"e_1_2_7_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01706.x"},{"key":"e_1_2_7_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1993.tb18343.x"},{"key":"e_1_2_7_45_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.1998.13.9.1420"},{"key":"e_1_2_7_46_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199901000-00004"},{"key":"e_1_2_7_47_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090510"},{"key":"e_1_2_7_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01310.x"},{"key":"e_1_2_7_49_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080480"},{"key":"e_1_2_7_50_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090628"},{"key":"e_1_2_7_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6101(02)00045-X"},{"key":"e_1_2_7_52_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.070066"},{"key":"e_1_2_7_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2003.10.019"},{"key":"e_1_2_7_54_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190500175049"},{"key":"e_1_2_7_55_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090375"},{"key":"e_1_2_7_56_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1384.035"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0765.2011.01445.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0765.2011.01445.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T08:38:57Z","timestamp":1698655137000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0765.2011.01445.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11,29]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1111\/j.1600-0765.2011.01445.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0765.2011.01445.x","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11,29]]}}}