{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:48:14Z","timestamp":1790858894601,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T00:00:00Z","timestamp":1328486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p><jats:italic>Adibrad M, Deyhimi P, Ganjalikhani Hakemi M, Behfarnia P, Shahabuei M, Rafiee L. Signs of the presence of Th17 cells in chronic periodontal disease. J Periodont Res 2012; 47: 525\u2013531. \u00a9 2012 John Wiley &amp; Sons A\/S<\/jats:italic><\/jats:p><jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> The aim of this study was to identify the specific markers of T helper 17 (Th17) cells and their variations in people suffering from chronic periodontal disease in comparison with normal control subjects.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> In 30 patients with periodontitis and 30 normal control subjects, the mRNA expressions of interleukin (IL)\u201017A and retinoic orphan receptor\u2003C2 (RORC2) were measured by quantitative RT\u2010PCR. The protein levels of IL\u201017A and RORC2 were also evaluated by immunohistochemistry. The levels of these markers were compared between healthy and diseased periodontal tissues by the Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010test.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> In periodontal lesions, <jats:italic>IL\u201017A<\/jats:italic> and <jats:italic>RORC2<\/jats:italic> were significantly overexpressed compared with normal tissues. According to our immunohistochemical analysis, the number of IL\u201017A\u2010positive cells and RORC2\u2010positive cells was significantly greater in periodontal lesions compared with control sites. Moreover, there was a positive correlation between the presence of <jats:italic>IL\u201017A<\/jats:italic> and <jats:italic>RORC2<\/jats:italic> transcript and protein content levels in the gingiva of diseased patients.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The results demonstrated a significant increase in the number of some specific markers of Th17 cells in patients suffering from periodontal disease in comparison with normal control subjects.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2011.01464.x","type":"journal-article","created":{"date-parts":[[2012,2,6]],"date-time":"2012-02-06T15:01:24Z","timestamp":1328540484000},"page":"525-531","source":"Crossref","is-referenced-by-count":68,"title":["Signs of the presence of Th17 cells in chronic periodontal 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