{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:34:35Z","timestamp":1791120875148,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T00:00:00Z","timestamp":1335225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p><jats:italic>Oshiro A, Iseki S, Miyauchi M, Terashima T, Kawaguchi Y, Ikeda Y, Shinomura T. Lipopolysaccharide induces rapid loss of follicular dendritic cell\u2010secreted protein in the junctional epithelium. J Periodont Res 2012; 47: 689\u2013694. \u00a9 2012 John Wiley &amp; Sons A\/S<\/jats:italic><\/jats:p><jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> We have previously reported that mRNA encoding follicular dendritic cell\u2010secreted protein (FDC\u2010SP) is expressed specifically in the junctional epithelium at the gingival crevice. Other tissues, such as tonsil, prostate gland and trachea, also express high levels of FDC\u2010SP. These tissues participate in a range of functions closely related to innate immunity. Therefore, it is hypothesized that FDC\u2010SP plays a crucial role in close association with the host defense system within the gingival crevice. Accordingly, the main aim of this study was to investigate the expression and localization of FDC\u2010SP in and around the junctional epithelium and to observe the dynamic changes of FDC\u2010SP in experimental inflammation.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> We examined, immunohistochemically, the expression of FDC\u2010SP in the junctional epithelium using a specific antibody raised in rabbit after immunization with a synthetic peptide derived from the hydrophilic region of FDC\u2010SP. Experimental inflammation was induced in the upper molars of Wistar rats by applying bacterial lipopolysaccharide (LPS; 5\u2003mg\/mL in sterile saline) for 1\u2003h.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> We confirmed that FDC\u2010SP is present in the junctional epithelium in a pattern that is consistent with the expression of FDC\u2010SP mRNA. Of special interest is that no FDC\u2010SP was detectable in the junctional epithelium 3 h after transient topical treatment with LPS.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The presence of FDC\u2010SP in the junctional epithelium and its loss after LPS treatment strongly support our hypothesis of FDC\u2010SP playing a crucial role in close association with the host defense system within the gingival crevice.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2012.01482.x","type":"journal-article","created":{"date-parts":[[2012,4,24]],"date-time":"2012-04-24T08:36:13Z","timestamp":1335256573000},"page":"689-694","source":"Crossref","is-referenced-by-count":21,"title":["Lipopolysaccharide induces rapid loss of follicular dendritic cell\u2010secreted protein in the junctional epithelium"],"prefix":"10.1111","volume":"47","author":[{"given":"A.","family":"Oshiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Iseki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Miyauchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Terashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Shinomura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,4,24]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M800719200"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00097.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0757.2002.03007.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2005.00141.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.10.1139"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004180100298"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.10.076"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2004.10.009"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1462-5822.2007.00901.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2836(84)90192-X"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0765.2003.00694.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2009.01258.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr060065m"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.11.048"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508400102"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.5.2381"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2008.00448.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2007.07.014"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0765.2012.01482.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0765.2012.01482.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T14:13:20Z","timestamp":1698675200000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0765.2012.01482.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4,24]]},"references-count":18,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["10.1111\/j.1600-0765.2012.01482.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0765.2012.01482.x","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,4,24]]}}}