{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T06:12:35Z","timestamp":1789711955008,"version":"4.0.1"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T00:00:00Z","timestamp":1342656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>\n                    <jats:bold>Background and Objective:\u2002<\/jats:bold>\n                    Cytokines produced by various cells are strong local mediators of inflammation. Mucosa\u2010associated epithelial chemokine (CCL28), interleukin\u20108 (IL\u20108), interleukin\u20101beta (IL\u20101\u03b2) and tumor necrosis factor\u2010alpha (TNF\u2010\u03b1) are major cytokines that play important roles in the periodontal inflammatory process. In this study we aimed to compare the levels of CCL28, IL\u20108, IL\u20101\u03b2 and TNF\u2010\u03b1 in the gingival crevicular fluid of both periodontally healthy subjects and in subjects diagnosed with gingivitis, chronic periodontitis and generalized aggressive periodontitis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Material and Methods:\u2002<\/jats:bold>\n                    A total of 84 subjects participated in the study: 21 subjects had gingivitis, 21 subjects had chronic periodontitis, 21 subjects had generalized aggressive periodontitis and 21 were periodontally healthy. The levels of CCL28, IL\u20108, IL\u20101\u03b2 and TNF\u2010\u03b1 were analyzed using enzyme\u2010linked immune sorbent assay (ELISA).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:\u2002<\/jats:bold>\n                    The total levels of CCL28 and IL\u20108 in the gingival crevicular fluid of the generalized aggressive periodontitis group (324.74\u2003\u00b1\u200342.62\u2003pg\/30\u2003s, 487.62\u2003\u00b1\u200349.21\u2003pg\/30\u2003s) were significantly higher than those of the chronic periodontitis group (268.81\u2003\u00b1\u200328.64\u2003pg\/30\u2003s, 423.65\u2003\u00b1\u200335.24\u2003pg\/30\u2003s), the gingivitis group (146.35\u2003\u00b1\u200317.46\u2003pg\/30\u2003s, 310.24\u2003\u00b1\u200348.20\u2003pg\/30\u2003s) and the periodontally healthy group (92.46\u2003\u00b1\u200322.04\u2003pg\/30\u2003s, 148.41\u2003\u00b1\u200324.64\u2003pg\/30\u2003s). Similarly, the total levels of IL\u20101\u03b2 and TNF\u2010\u03b1 in the generalized aggressive periodontitis group (110.23\u2003\u00b1\u20039.20\u2003pg\/30\u2003s, 1284.46\u2003\u00b1\u200386.32\u2003pg\/30\u2003s) were significantly higher than those in the chronic periodontitis group (423.65\u2003\u00b1\u200335.24\u2003pg\/30\u2003s, 82.64\u2003\u00b1\u20039.12 pg\/30\u2003s), the gingivitis group (52.10\u2003\u00b1 7.15\u2003pg\/30\u2003s, 824.24\u2003\u00b1\u200344.68\u2003pg\/30\u2003s) and the periodontally healthy group (36.44\u2003\u00b1 8.86\u2003pg\/30\u2003s, 628.26\u2003\u00b1 34.61\u2003pg\/30\u2003s).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusion:\u2002<\/jats:bold>\n                    CCL28, IL\u20108, IL\u20101\u03b2 and TNF\u2010\u03b1 may play key roles in the host response to inflammation in periodontal diseases. As the severity of periodontal diseases increases, destruction of periodontal tissues also increases. Inflammation is one among many factors that trigger periodontal tissue destruction. Identification of the mediators that influence the development and progression of inflammation in periodontal diseases may be very important in understanding the prognoses of periodontal diseases.\n                  <\/jats:p>","DOI":"10.1111\/j.1600-0765.2012.01500.x","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T17:38:12Z","timestamp":1342805892000},"page":"44-51","source":"Crossref","is-referenced-by-count":115,"title":["Comparison of CCL28, interleukin\u20108, interleukin\u20101\u03b2 and tumor necrosis factor\u2010alpha in subjects with gingivitis, chronic periodontitis and generalized aggressive periodontitis"],"prefix":"10.1111","volume":"48","author":[{"given":"A. 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