{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:07:01Z","timestamp":1792642021775,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,7,19]],"date-time":"2012-07-19T00:00:00Z","timestamp":1342656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:p><jats:italic>Jeong E, Lee J\u2010Y, Kim S\u2010J, Choi J. Predominant immunoreactivity of<\/jats:italic> Porphyromonas gingivalis <jats:italic>heat shock protein in autoimmune diseases. J Periodont Res 2012; 47: 811\u2013816. \u00a9 2012 John Wiley &amp; Sons A\/S<\/jats:italic><\/jats:p><jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Autoimmune diseases, including atherosclerosis, diabetes mellitus and rheumatoid arthritis, can be triggered and aggravated by the pathogen\u2010driven antigenic peptide from <jats:italic>Porphyromonas gingivalis<\/jats:italic> HSP60. <jats:italic>P. gingivalis<\/jats:italic> is the major pathogen of chronic periodontitis, which is a global epidemic prevalent in two\u2010thirds of the adult population. The monoclonal antibody raised against peptide 19 (Pep19: TLVVNRLRGSLKICAVKAPG) from <jats:italic>P.\u00a0gingivalis<\/jats:italic> HSP60 was polyreactive to the human homolog. The aim of this study was to determine if Pep19 from <jats:italic>P.\u00a0gingivalis<\/jats:italic> HSP60 manifests itself as a predominant antigen in infection\u2010triggered autoimmune diseases.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Pep19 from <jats:italic>P.\u00a0gingivalis<\/jats:italic> HSP60<jats:italic>, Mycobacterium tuberculosis<\/jats:italic> HSP60 and <jats:italic>Chlamydia pneumoniae<\/jats:italic> HSP60 was synthesized for comparative recognition by the sera from patients with atherosclerosis, type 2 diabetes and rheumatoid arthritis, all with ongoing periodontal disease, and by the sera of a control group of patients with periodontal disease but with no history of atherosclerosis, type 2 diabetes or rheumatoid arthritis.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Of the Pep19 peptides from <jats:italic>P.\u00a0gingivalis<\/jats:italic> HSP60<jats:italic>, M.\u00a0tuberculosis<\/jats:italic> HSP60 and <jats:italic>C.\u00a0pneumoniae<\/jats:italic> HSP60, Pep19 from <jats:italic>P.\u00a0gingivalis<\/jats:italic> HSP60 was the peptide epitope predominantly and most consistently recognized by the serum samples of the four disease groups (chronic periodontitis, atherosclerosis, type 2 diabetes mellitus and rheumatoid arthritis).<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> Seroreactivity to Pep19 of <jats:italic>P.\u00a0gingivalis<\/jats:italic> HSP60, an oral pathogen, was predominant in patients with autoimmune disease with ongoing periodontal disease.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2012.01501.x","type":"journal-article","created":{"date-parts":[[2012,7,20]],"date-time":"2012-07-20T21:38:07Z","timestamp":1342820287000},"page":"811-816","source":"Crossref","is-referenced-by-count":36,"title":["Predominant immunoreactivity of <i>Porphyromonas gingivalis<\/i> heat shock protein in autoimmune diseases"],"prefix":"10.1111","volume":"47","author":[{"given":"E.","family":"Jeong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u2010Y.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u2010J.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/jaut.2000.0499"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200114235"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2003.11.011"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri1882"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(02)02135-6"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.181.3.943"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910208100511"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408301209"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2010.01339.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00190.x"},{"key":"e_1_2_5_12_2","unstructured":"Glossary of Periodontal Terms 4th edition.American Academy of Periodontology 2001."},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.88.6.2987"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-s064"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310302"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510375281"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-302X.2005.00230.x"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/154405910708600105"},{"key":"e_1_2_5_19_2","unstructured":"ChoiJ KimK.Vaccination of Pep19 fromPorphyromonas gingivalisHSP60 aggravates both periodontitis and atherosclerosis. 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