{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:12:03Z","timestamp":1792735923865,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,29]],"date-time":"2012-07-29T00:00:00Z","timestamp":1343520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p><jats:italic>Chang P\u2010C, Chien L\u2010Y, Ye Y, Kao M\u2010J. Irradiation by light\u2010emitting diode light as an adjunct to facilitate healing of experimental periodontitis<\/jats:italic> in vivo. <jats:italic>J Periodont Res 2013; 48: 135\u2013143. \u00a9 2012 John Wiley &amp; Sons A\/S<\/jats:italic><\/jats:p><jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> This study evaluated the biostimulatory effect of 660\u2003nm light\u2010emitting diode (LED) as an adjunct in the treatment of experimental periodontitis.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Ninety\u2010six Sprague\u2010Dawley rats underwent experimental periodontitis by placement of a silk ligature followed with or without additive <jats:italic>Porphyromonas\u00a0gingivalis<\/jats:italic> lipopolysaccharide (<jats:italic>Pg<\/jats:italic>\u2010LPS) injection. Irradiation with LED light was performed at varying energy densities of 5, 10 and 15\u2003J\/cm<jats:sup>2<\/jats:sup>, 1\u2003d after debridement and detoxification. Rats were killed at 3, 7 and 14\u2003d after irradiation with LED light, and the effect of irradiation was evaluated by descriptive histology and quantitative measurements of periodontal bone loss, inflammatory infiltration and cellular proliferation.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Reduction of inflammation, accelerated collagen deposition and realignment was noted following irradiation with LED light at densities of 10 and 15\u2003J\/cm<jats:sup>2<\/jats:sup>, and temporary reduction of periodontal bone loss, as well as bundle bone apposition, was noted at day 3 in rats treated with 10\u2003J\/cm<jats:sup>2<\/jats:sup> light. The biomodulatory effect was stronger in sites treated with <jats:italic>Pg<\/jats:italic>\u2010LPS injection. In sites without <jats:italic>Pg<\/jats:italic>\u2010LPS injection, temporary reduction of inflammation was noted in all LED light\u2010irradiated specimens at day 3. No significant change in cellular proliferation was noted in any LED light\u2010treated group.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> LED light (660\u2003nm) with an energy density of 10\u2003J\/cm<jats:sup>2<\/jats:sup> appeared suitable as an adjunct modality for periodontitis by temporarily reducing inflammation, facilitating collagen realignment and bundle bone deposition. Future studies will aim to amplify the biostimulatory effect of LED light by adding a supplementary medium or repeated irradiation.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2012.01511.x","type":"journal-article","created":{"date-parts":[[2012,7,30]],"date-time":"2012-07-30T01:42:28Z","timestamp":1343612548000},"page":"135-143","source":"Crossref","is-referenced-by-count":22,"title":["Irradiation by light\u2010emitting diode light as an adjunct to facilitate healing of experimental periodontitis <i>in 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