{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:34:18Z","timestamp":1770438858850,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T00:00:00Z","timestamp":1343347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Periodontal Research"],"published-print":{"date-parts":[[2013,4]]},"abstract":"<jats:p>\n<jats:italic>Fang Y, Wang L\u2010P, Du F\u2010L, Liu W\u2010J, Ren G\u2010L. Effects of insulin\u2010like growth factor I on alveolar bone remodeling in diabetic rats. J Periodont Res 2013; 48: 144\u2013150. \u00a9 2012 John Wiley &amp; Sons A\/S<\/jats:italic>\n<\/jats:p><jats:p><jats:bold>Background and Objective:\u2002<\/jats:bold> Diabetes is a chronic hyperglycemic disorder and results in a tendency to develop osteoporosis. Furthermore, the delayed healing of tooth\u2010extraction wounds, the activation of alveolar resorption and the suppressed formation of bone around implants are difficult for dentists to resolve. In diabetes, insulin\u2010like growth factor I (IGF\u2010I) appears to enhance the differentiation of osteoblasts and to activate the mineralization of bone. Hence, the aim of this study was to investigate the effects of insulin\u2010like growth factor I on the remodeling of alveolar bone in diabetic rats.<\/jats:p><jats:p><jats:bold>Material and Methods:\u2002<\/jats:bold> Diabetes was induced in 40 male Sprague\u2010Dawley rats by intravenous administration of alloxan. The teeth of the rats were extracted to investigate remodeling of alveolar bone. Insulin\u2010like growth factor I was administered, via intraperitoneal injection, to diabetic rats following tooth extraction. The remodeling of alveolar bone was determined using radiographic data, histological analyses and tetracycline fluorescence labeling.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Compared with the control group, diabetes decreased alveolar bone formation. The height of alveolar bone and the bone\u2010formation rate was significantly lower in the untreated diabetic group than in the control group or in the treated rats. Treatment with insulin\u2010like growth factor I not only regulated abnormal blood glucose levels but also increased the height of the alveolar bone and increased the bone\u2010formation rate relative to the results in diabetic animals. Furthermore, the expression of glucose transporter\u20101, the main transporter of glucose, was changed by hyperglycemia.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> The results suggest that insulin\u2010like growth factor I treatment increases the volume of newly formed bone following tooth extraction and normalizes the expression of glucose transporter\u20101 in diabetic rats, which may play an important role in bone formation and mineralization.<\/jats:p>","DOI":"10.1111\/j.1600-0765.2012.01512.x","type":"journal-article","created":{"date-parts":[[2012,7,27]],"date-time":"2012-07-27T22:17:31Z","timestamp":1343427451000},"page":"144-150","source":"Crossref","is-referenced-by-count":29,"title":["Effects of insulin\u2010like growth factor I on alveolar bone remodeling in diabetic rats"],"prefix":"10.1111","volume":"48","author":[{"given":"Y.","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.\u2010P.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.\u2010L.","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.\u2010J.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.\u2010L.","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.50.7.1627"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.10.2875"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220072"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2011.01354.x"},{"key":"e_1_2_6_6_2","first-page":"618","article-title":"Downregulation of retinal GLUT1 in diabetes by ubiquitinylation","volume":"10","author":"Fernandes R","year":"2004","journal-title":"Mol Vis"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/meta.2001.24202"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.2.527"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1719"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2004.11.024"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.1.5659"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi020084j"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6750-11-37"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.49.12.2021"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2004.00723.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2006.07.007"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2005.11.010"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027487"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2012.01478.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034510388037"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2502"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-2364"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1378"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.2174\/156800912798888974"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1080\/03008200591008437"}],"container-title":["Journal of Periodontal Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0765.2012.01512.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0765.2012.01512.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T14:08:11Z","timestamp":1698674891000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0765.2012.01512.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,27]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,4]]}},"alternative-id":["10.1111\/j.1600-0765.2012.01512.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0765.2012.01512.x","archive":["Portico"],"relation":{},"ISSN":["0022-3484","1600-0765"],"issn-type":[{"value":"0022-3484","type":"print"},{"value":"1600-0765","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,27]]}}}