{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T13:33:52Z","timestamp":1758807232271},"reference-count":24,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,3,13]],"date-time":"2009-03-13T00:00:00Z","timestamp":1236902400000},"content-version":"vor","delay-in-days":10178,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Pharmacologica et Toxicologica"],"published-print":{"date-parts":[[1981,5]]},"abstract":"<jats:p><jats:bold>Abstract: <\/jats:bold> A detailed knowledge of fluoride (F) pharmakokinetics is necessary if its pharmacologic and toxicologic effects are to be adequately understood. In the present study plasma F concentrations have been analysed using repeated blood samples taken from the ethmoidal sinus of rats given 25,50,100 and 150 p.p.m. F in drinking water <jats:italic>ad libitum<\/jats:italic> for 79 days. A close relationship between the F\u2010concentration in the drinking water and plasma F concentrations was found. When the administration of F was stopped, a rapid decline in plasma F concentration was noted during 48 hrs in all groups. The plasma F concentrations in the 25 p.p.m. group returned to preexperimental levels but remained elevated in the other groups. The F concentrations of dentin and bone were determined and calculated on a dry fat free basis. The results show that there was a close relationship between plasma, bone and dentin concentrations.<\/jats:p>","DOI":"10.1111\/j.1600-0773.1981.tb01643.x","type":"journal-article","created":{"date-parts":[[2010,7,29]],"date-time":"2010-07-29T22:42:25Z","timestamp":1280443345000},"page":"433-437","source":"Crossref","is-referenced-by-count":13,"title":["Relationship between Plasma, Dentin and Bone Fluoride Concentrations in Rats following Long\u2010term Fluoride Administration"],"prefix":"10.1111","volume":"48","author":[{"given":"J.","family":"Ekstrand","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Ekberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Hammarstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,3,13]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02010348"},{"key":"e_1_2_1_3_1","first-page":"93","volume-title":"Fluorides and human health.","author":"Armstrong W. 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