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Decreased DA levels but increased L\u2010DOPA accumulation were also seen in cyanide\u2010treated animals after inhibition of neuronal L\u2010aromatic amino decarboxylase. In rats given a non\u2010lethal dose of NaCN, 2.5 mg\/kg intraperitoneally, 30 min. before sacrifice and L\u2010DOPA, 100 mg\/kg intraperitoneally, 25 min. before sacrifice, regional L\u2010DOPA levels were not significantly changed, but the striatal DA levels were diminished compared to controls. Decreased DA levels might indicate that cyanide inhibits the synthesis of brain DA. However, both increased L\u2010DOPA and increased accumulation of L\u2010DOPA after neuronal decarboxylase were observed after cyanide. Furthermore, we have earlier reported that lethal doses of NaCN decreased the DA metabolite HVA in the striatum but did not significantly change the oxidatively deaminated metabolite of DA, DOPAC. Inhibition of L\u2010aromatic amino acid decarboxylase appears to play a minor role in causing decreased striatal DA levels. 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