{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T04:44:57Z","timestamp":1764132297066},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,3,17]],"date-time":"2004-03-17T00:00:00Z","timestamp":1079481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:p><jats:bold>Background\/Purpose: <\/jats:bold> Ultraviolet (UV) exposure of mammalian skin induces local and systemic immunosuppression. In mice it has been proposed that systemic immunosuppression is mediated by an UV\u2010induced cytokine cascade involving systemic interleukin (IL)\u20104 and IL\u201010 and a reduction in IL\u201012 activity. To investigate whether there was a parallel mechanism in humans we examined the effect of whole\u2010body narrowband ultraviolet B (UVB) (311\u2013313\u2003nm; TL\u201001) and ultraviolet A (UVA)\u20101 (340\u2013400\u2003nm) on serum cytokine levels.<\/jats:p><jats:p><jats:bold>Methods\/Results: <\/jats:bold> In a first study, five male psoriatic subjects were whole\u2010body irradiated with three sessions of a standard UVB (TL\u201001) phototherapy regimen previously shown to cause downregulation of natural killer cell activity and T helper 1 (Th1) and Th2 cytokine production by peripheral blood mononuclear cells. Enzyme\u2010linked immunoabsorbent assay (ELISA) of sera taken before and after the third session showed no effect of phototherapy on IL\u201010 and tumour necrosis factor\u2010\u03b1 (TNF\u2010\u03b1). In a second study, five healthy subjects received three whole\u2010body exposures of UVB (TL\u201001) and five other healthy subjects received three exposures of UVA\u20101 on alternate days (total 22\u2003J\/cm<jats:sup>2<\/jats:sup>). Blood samples were taken before the first irradiation and at 0, 4, 8, 12, 14, 24 and 48\u2003h after the third irradiation. The sera were subsequently analysed for IL\u201010, IL\u201012, IL\u20108, IL\u20101\u03b2 and TNF\u2010\u03b1, by ELISA. The levels of IL\u20101\u03b2 and TNF\u2010\u03b1 were below detection limits (&lt;5\u2003pg\/ml), while no significant change in the levels of IL\u201010, IL\u201012 or IL\u20108 was detected as a result of either TL\u201001 or UVA\u20101.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> It seems unlikely that a modulation in these circulating cytokines assessed in this study accounts for systemic UV\u2010induced immunosuppression in human subjects.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2004.00089.x","type":"journal-article","created":{"date-parts":[[2004,3,17]],"date-time":"2004-03-17T11:36:49Z","timestamp":1079523409000},"page":"76-80","source":"Crossref","is-referenced-by-count":22,"title":["Whole\u2010body UVB (TL\u201001) or UVA\u20101 irradiation does not alter the levels of immunomodulatory cytokines in the serum of human 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