{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T13:35:12Z","timestamp":1772458512626,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,7,6]],"date-time":"2004-07-06T00:00:00Z","timestamp":1089072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Polymorphous light eruption (PLE) is the most common photodermatosis. While its etiology still remains elusive, pathogenesis seems to involve UVA\u2010induced oxidative stress and subsequent deregulation of antioxidative immune responses. Only few and often ineffective prophylactic and therapeutic measures exist to date.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> In our randomized, double\u2010blind, placebo\u2010controlled clinical study, we compared the efficacy of a new topical formulation, consisting of 0.25%\u03b1\u2010glucosylrutin (AGR) (a natural, modified flavonoid), 1% tocopheryl acetate (vitamin E) and a broad\u2010spectrum, highly UVA\u2010protective sunscreen (SPF 15) in a hydrodispersion gel vehicle, to a sunscreen\u2010only gel and vehicle. Thirty patients with a history of PLE were pretreated with either the above formulation, a similar preparation (with the same concentration for vitamin E and AGR, but a different UV filter system), placebo or a SPF 15 sunscreen\u2010only gel, 30\u2003min prior to daily photoprovocation with UVA irradiations of 60\u2013100\u2003J\/cm<jats:sup>2<\/jats:sup> to 5 \u00d7 5\u2003cm<jats:sup>2<\/jats:sup> areas on the upper arms.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> After 4 days, results revealed a statistically highly significant difference (<jats:italic>P<\/jats:italic>&lt;0.001) between the antioxidant containing formulations and placebo, and sunscreen\u2010only formulation, respectively, in experimentally eliciting PLE. While only one patient developed clinical signs of PLE with accompanying itch in the area treated with the new antioxidant UV\u2010protective gel formulation, 62.1% of the placebo\u2010treated areas and 41.3% of the sunscreen\u2010only treated areas showed mild to moderate signs of PLE.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> Combining a potent antioxidant with a broad\u2010spectrum, highly UVA\u2010protective sunscreen is far more effective in preventing PLE than sunscreen alone or placebo and should thus be employed as the prophylaxis of choice for PLE.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2004.00103.x","type":"journal-article","created":{"date-parts":[[2004,7,6]],"date-time":"2004-07-06T08:12:49Z","timestamp":1089101569000},"page":"200-204","source":"Crossref","is-referenced-by-count":26,"title":["Polymorphous light eruption (PLE) and a new potent antioxidant and UVA\u2010protective formulation as prophylaxis"],"prefix":"10.1111","volume":"20","author":[{"given":"I. 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