{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T02:33:32Z","timestamp":1769222012211,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,9,20]],"date-time":"2004-09-20T00:00:00Z","timestamp":1095638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p><jats:bold>Background\/purpose: <\/jats:bold> Photodynamic therapy (PDT) is a promising treatment for various skin tumors and other skin diseases. We investigated the potential therapeutic effects of PDT using ATX\u2010S10(Na) ointment and a diode laser in mouse skin models of experimental skin tumors as well as transplanted human samples of superficial skin tumors and lesional psoriatic skin.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> ATX\u2010S10(Na) ointment (1% w\/v) was introduced into tape\u2010stripped mouse skin, transplanted squamous cell carcinoma (SCC) samples and human skin diseases after topical application, then PDT was performed.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> ATX\u2010S10(Na) ointment (1% w\/v) was introduced effectively into tape\u2010stripped mouse skin and transplanted SCC samples after topical application, but was not detected after 48\u2003h, as assessed by fluorescence microscopy. PDT, using 1% ATX\u2010S10(Na) ointment and diode laser (50\u2003J\/cm<jats:sup>2<\/jats:sup>), was found to decrease epidermal thickness in 12\u20100\u2010tetradecanoylphorbol\u201013\u2010acetate (TPA)\u2010treated mouse skin by 6 days. PDT with 1% ATX\u2010S10(Na) ointment and diode laser (150\u2003J\/cm<jats:sup>2<\/jats:sup>) was also effective for transplanted SCC, and tumors were eliminated by 6 weeks. PDT against Bowen disease, basal\u2010cell carcinoma, and psoriasis xenografts onto SCID mice also showed marked suppression of tumor growth and cell proliferation, respectively.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> Our results indicate that ATX\u2010S10(Na)\u2010PDT is an effective treatment for various skin tumors and psoriasis in experimental mouse models.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2004.00108.x","type":"journal-article","created":{"date-parts":[[2004,9,20]],"date-time":"2004-09-20T15:26:50Z","timestamp":1095694010000},"page":"257-265","source":"Crossref","is-referenced-by-count":11,"title":["A novel ATX\u2010S10(Na) photodynamic therapy for human skin tumors and benign hyperproliferative skin"],"prefix":"10.1111","volume":"20","author":[{"given":"Hidetoshi","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Nakajima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Sakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Iizuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,20]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"143","article-title":"Photodynamic therapy with endogenous protophorphyrin IX","volume":"6","author":"Kennedy JC","year":"1990","journal-title":"basic principles and present clinical 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