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However, a therapeutical benefit of PDT is also evident for inflammatory dermatoses like localized scleroderma, acne vulgaris and granuloma annulare. Recent work has been focused on the development and evaluation of topical photosensitizers like the heme precursor 5\u2010aminolevulinic acid (5\u2010ALA) or its methyl ester (methyl aminolevulinate) inducing photosensitizing porphyrins. These drugs do not induce strong generalized cutaneous photosensitization like the systemically applied porphyrins or their derivatives. For dermatological purposes, incoherent lamps or light\u2010emitting diode arrays can be used for light activation. Depending on the applied light dose and the concentration of the photosensitizer either cytotoxic effects resulting in tumor destruction or immunomodulatory effects improving the inflammatory conditions occur. Treating superficial oncologic lesions (tumor thickness &lt;2\u20133\u2003mm) cure rates achieved by PDT are equal to the cure rates of the respective standard therapeutic procedure. The benefits of PDT are the low level of invasiveness and the excellent cosmetic results after treatment.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2005.00147.x","type":"journal-article","created":{"date-parts":[[2005,5,11]],"date-time":"2005-05-11T08:35:28Z","timestamp":1115800528000},"page":"142-149","source":"Crossref","is-referenced-by-count":110,"title":["Photodynamic therapy in dermatology \u2013 an 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