{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T23:50:19Z","timestamp":1776988219605,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,24]],"date-time":"2005-11-24T00:00:00Z","timestamp":1132790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Photodynamic therapy (PDT) is useful for the treatment of epidermal neoplasia but may also have use in the treatment of inflammatory dermatoses. The purpose of this study was to evaluate the safety and efficacy of PDT in the treatment of acne on the face.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Eight patients with mild\u2010to\u2010moderate acne vulgaris on the face were treated with one session of topical aminolevulinic acid (ALA)\u2010PDT using a red light. Each patient's face was divided into two areas (right side and left side) for ALA\u2010PDT and untreated control. Twenty percent topical ALA was applied with 4\u2003h occlusion, and 18\u2003J\/cm<jats:sup>2<\/jats:sup> red light (630\u00b163\u2003nm) was administered. Each patient's acne was visually assessed by a spot count of both inflamed and non\u2010inflamed lesions at baseline and at 1, 3, and 6 months following PDT.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> At 1, 3, and 6 months, the mean percentage reduction in inflamed lesions count was 27.6%, 37.9%, and 41.9%, respectively, in the ALA\u2010PDT\u2010treated area, whereas in the control area, it was 8.0%, 14.7%, and 15.4%, respectively, compared with the baseline. This showed a higher reduction of a spot count of inflamed lesions in the ALA\u2010PDT\u2010treated area, which was statistically significant (<jats:italic>P<\/jats:italic>&lt;0.05). There was a slightly higher reduction of a spot count of non\u2010inflamed lesions in the ALA\u2010PDT\u2010treated area, which was statistically not significant (<jats:italic>P<\/jats:italic>&gt;0.05). The adverse effects were minimal.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> ALA\u2010PDT with red light was found to be effective in the reduction of the number of inflamed lesions in patients with mild\u2010to\u2010moderate acne vulgaris, with no significant short\u2010term adverse effects.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2005.00181.x","type":"journal-article","created":{"date-parts":[[2005,11,24]],"date-time":"2005-11-24T14:41:54Z","timestamp":1132843314000},"page":"322-325","source":"Crossref","is-referenced-by-count":47,"title":["Topical aminolevulinic acid\u2010photodynamic therapy for the treatment of acne vulgaris"],"prefix":"10.1111","volume":"21","author":[{"given":"Seok\u2010Beom","family":"Hong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mu\u2010Hyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,24]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1515\/znc-1984-3-417","article-title":"Photoinactivation of propionibacterium acnes by near\u2010ultraviolet light","volume":"39","author":"Kjeldstad B.","year":"1984","journal-title":"Z Naturforsch"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000246114"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1986.tb05592.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0937"},{"key":"e_1_2_5_6_2","first-page":"891","article-title":"Phototoxic damage to sebaceous glands and hair follicles of mice after systemic administration of 5\u2010aminolevulinic acid correlates with localized protoporphyrin IX fluorescence","volume":"136","author":"Divaris DX","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1992.tb04222.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00046.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04086.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.9.1093"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2003.tb00644.x"},{"key":"e_1_2_5_12_2","first-page":"597","article-title":"Therapy of acne with visible light. Decreased irradiation time by using a blue\u2010light high\u2010energy lamp","volume":"176","author":"Meffert H","year":"1990","journal-title":"Dermatol Monatsschr"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03528.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1997)20:1<56::AID-LSM9>3.0.CO;2-Y"},{"key":"e_1_2_5_15_2","first-page":"127","article-title":"Biostimulation of wound healing by lasers","volume":"13","author":"Abergel RP","year":"1987","journal-title":"experimental approaches in animal models and in fibroblast cultures"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0781.2005.00181.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0781.2005.00181.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T09:00:27Z","timestamp":1697274027000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0781.2005.00181.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,24]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1111\/j.1600-0781.2005.00181.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0781.2005.00181.x","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,24]]}}}