{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:57:07Z","timestamp":1781578627771,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,24]],"date-time":"2005-11-24T00:00:00Z","timestamp":1132790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Psoralen ultraviolet A (PUVA) is a widely used first\u2010line therapy for treatment of early cutaneous T\u2010cell lymphoma. Narrow band UVB (UVB\u2010NB) (311\u2003nm) has been recently introduced as another effective line of treatment. It is postulated that the efficacy of UVB\u2010NB could be enhanced by addition of psoralen.<\/jats:p><jats:p><jats:bold>Aim: <\/jats:bold> The aim of the present work was to compare the clinical and histopathologic efficacy of PUVA and UVB\u2010NB in the treatment of early\u2010stage MF (stages IA, IB and IIA), and to evaluate whether psoralen adds to the efficacy of UVB\u2010NB or not.<\/jats:p><jats:p><jats:bold>Patients and Methods: <\/jats:bold> Twenty patients (stage IA, IB or IIA) were divided into two equal groups: group I received UVB\u2010NB on the right body half vs. PUVA on the left side of the body for 48 sessions, and group II received PUVB\u2010NB on the right side of the body vs. PUVA on the left side for 36 sessions. The sessions were administered three times weekly.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> In group I, almost equal results were obtained on both sides, i.e., UVB\u2010NB and PUVA were equally effective in the treatment of early stages of MF, both clinically and histopathologically. In group II, PUVB\u2010NB was found to be as effective as conventional PUVA in the treatment of early\u2010stage mycosis fungoides, also on both clinical and histopathological grounds.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> UVB\u2010NB phototherapy should be included among the initial therapeutic options of mycosis fungoides in view of its efficacy, convenience, and likelihood of fewer long\u2010term adverse effects. Addition of psoralen does not seem to enhance its therapeutic efficacy.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2005.00183.x","type":"journal-article","created":{"date-parts":[[2005,11,24]],"date-time":"2005-11-24T14:41:54Z","timestamp":1132843314000},"page":"281-286","source":"Crossref","is-referenced-by-count":41,"title":["Narrow band UVB (311\u2003nm), psoralen UVB (311\u2003nm) and PUVA therapy in the treatment of early\u2010stage mycosis fungoides: a right\u2013left comparative study"],"prefix":"10.1111","volume":"21","author":[{"given":"M.","family":"El\u2010Mofty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"El\u2010Darouty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Salonas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bosseila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sobeih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Leheta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Nada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tawdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"El\u2010Enany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,24]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"1181","volume-title":"Dermatology, Chapter 68","author":"Heald PW","year":"1993"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197608)38:2<683::AID-CNCR2820380210>3.0.CO;2-V"},{"key":"e_1_2_6_4_2","first-page":"234","article-title":"Treatment of mycosis fungoides with photochemotherapy (PUVA)","volume":"33","author":"Herrmann J","year":"1995","journal-title":"long-term follow-up"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1986.tb00509.x"},{"key":"e_1_2_6_6_2","first-page":"203","article-title":"Alteration of lymphocyte functions by 8\u2010methoxypsoralen and longwave ultraviolet radiation","volume":"84","author":"Okamolo H","year":"1985","journal-title":"suppressive effect of PUVA on T-lymphocyte migration in vitro"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.02898.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12874666"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.135.11.1377"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.6.748"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120911"},{"key":"e_1_2_6_12_2","first-page":"234","article-title":"Treatment of mycosis fungoides with photochemotherapy (PUVA)","volume":"33","author":"Herrmann JJ","year":"1995","journal-title":"long-term follow-up"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00174.x"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70246-9"},{"key":"e_1_2_6_15_2","first-page":"215","article-title":"Narrowband UVB and psoralen\u2010UVA in the treatment of early\u2010stage mycosis fungoides","volume":"48","author":"Diederen PV","year":"2002","journal-title":"a retrospective study"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.110896"}],"container-title":["Photodermatology, Photoimmunology &amp; 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