{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T15:15:15Z","timestamp":1770995715569,"version":"3.50.1"},"reference-count":6,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,8,31]],"date-time":"2006-08-31T00:00:00Z","timestamp":1156982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Melatonin, the central neurohormone in circadian rhythm pathways, is recognized to have a variety of immune\u2010enhancing effects. It has previously been shown to reduce ultraviolet (UV) radiation\u2010induced erythema in mice and in humans, but there are as yet no published studies on the effects of melatonin on UV\u2010induced immunosuppression in humans.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> We investigated the effects of topical melatonin on solar\u2010simulated (ss) UV\u2010induced suppression of Mantoux reactions in 16 healthy, Mantoux\u2010positive volunteers. Melatonin (5%) and its vehicle were applied in a double\u2010blinded manner to separate areas on the lower back, immediately after each of three consecutive daily ssUV exposures. Various sites on the back received either no irradiation or one of three\u2010graded ssUV doses. Mantoux testing was performed at each site 24\u2003h after the final irradiation, and assessed 72\u2003h later using a reflectance erythema meter. In a separate group of 19 volunteers, the effect of melatonin on minimal erythema dose was assessed both visually and with an erythema meter.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> We found dose\u2010responsive UV\u2010induced suppression of the Mantoux response in the presence of both vehicle and melatonin; melatonin did not prevent UV\u2010induced immunosuppression in this model. Melatonin was also found to have no effect on the minimal erythema dose.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> Melatonin conferred no protection against immune suppression or sunburn when applied topically to human skin immediately after irradiation.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2006.00235.x","type":"journal-article","created":{"date-parts":[[2006,8,31]],"date-time":"2006-08-31T14:35:47Z","timestamp":1157034947000},"page":"267-269","source":"Crossref","is-referenced-by-count":8,"title":["Effect of topical melatonin on ultraviolet radiation\u2010induced suppression of Mantoux reactions in humans"],"prefix":"10.1111","volume":"22","author":[{"given":"Renae A.","family":"Howes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary M.","family":"Halliday","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diona L.","family":"Damian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,31]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"2575","article-title":"Melatonin","volume":"20","author":"Vijayalaxmi","year":"2002","journal-title":"from basic research to cancer treatment clinics"},{"key":"e_1_2_5_3_2","first-page":"176","article-title":"The cutaneous serotinergic\/melatonergic system","volume":"19","author":"Slominski A","year":"2002","journal-title":"securing a place under the sun"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02505248"},{"key":"e_1_2_5_5_2","first-page":"332","article-title":"Topical melatonin in combination with vitamins E and C protects skin from ultraviolet\u2010induced erythema","volume":"139","author":"Dreher F","year":"1998","journal-title":"a human study in vivo"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-2023(02)00208-6"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2003.35"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0781.2006.00235.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0781.2006.00235.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T23:24:06Z","timestamp":1697066646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0781.2006.00235.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,31]]},"references-count":6,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1111\/j.1600-0781.2006.00235.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0781.2006.00235.x","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,31]]}}}