{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:38:16Z","timestamp":1779233896562,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,8,31]],"date-time":"2006-08-31T00:00:00Z","timestamp":1156982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Mycosis fungoides (MF) is the most common primary cutaneous T\u2010cell lymphoma (CTCL). Unilesional MF is characterized by a limited involvement of the skin and a chronical, though indolent course. If lesions are refractory to topical steroids, therapies such as localized chemotherapy, photochemotherapy and radiotherapy are available. However, they have several acute and chronic side\u2010effects and toxicity may accumulate if repeated and protracted treatment cycles are delivered to refractory or relapsing lesions. The present study aims to assess the efficacy of photodynamic therapy (PDT) with topical methylaminolevulinate (MAL) in the treatment of unilesional MF.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Five patients were enrolled who had unilesional MF that did not respond to treatment with topical steroids, localized psoralen and UVA therapy or UVA1 phototherapies. A 20% MAL (Metvix cream<jats:sup>\u00ae<\/jats:sup>) cream was applied under occlusive dressing for 3\u2003h. Soon afterwards, skin was irradiated with 37.5\u2003J\/cm<jats:sup>2<\/jats:sup> of red light (635\u00b118\u2003nm) delivered by an Aktilite CL128 lamp (PhotoCure ASA) with an irradiance of 86\u2003W\/cm<jats:sup>2<\/jats:sup> at skin level. PDT was repeated once weekly until complete clearing of the lesions was obtained, or, in the case of partial clearing, the therapy was interupted when three successive treatments provided no further improvement. All patients underwent a skin biopsy before and after PDT.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> A complete remission was observed in four patients and a partial improvement in one. The median number of treatments was six (range 1\u20139). In no cases was recurrence seen at follow\u2010up (ranging from 12 to 34 months). Treatments were well tolerated and local anesthesia was never requested.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> In conclusion, here, PDT was seen to be an effective and well\u2010tolerated treatment option for unilesional MF.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2006.00246.x","type":"journal-article","created":{"date-parts":[[2006,8,31]],"date-time":"2006-08-31T14:35:47Z","timestamp":1157034947000},"page":"254-258","source":"Crossref","is-referenced-by-count":66,"title":["Photodynamic therapy with methylaminolevulinate as a valuable treatment option for unilesional cutaneous T\u2010cell lymphoma"],"prefix":"10.1111","volume":"22","author":[{"given":"Cristina","family":"Zane","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Venturini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Sala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piergiacomo","family":"Calzavara\u2010Pinton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,8,31]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_5_3_2","first-page":"283","article-title":"Unilesional cutaneous T\u2010cell lymphoma","volume":"42","author":"Heald PW","year":"2000","journal-title":"clinical features, therapy, and follow-up of 10 patients with a treatment responsive mycosis fungoides variant"},{"key":"e_1_2_5_4_2","first-page":"227","article-title":"Photodynamic therapy with topical methyl aminolevulinate for actinic keratosis","volume":"48","author":"Pariser DM","year":"2003","journal-title":"results of a prospective randomized multicenter trial"},{"issue":"3","key":"e_1_2_5_5_2","first-page":"231","article-title":"A phase III randomised study comparing photodynamic therapy (PDT) using methyl aminolevulinate or placebo cream in nodular basal cell carcinoma (NBCC)","volume":"17","author":"Foley P","year":"2003","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(83)90126-4"},{"key":"e_1_2_5_7_2","first-page":"1481","article-title":"Use of 5 aminolevulinic acid esters to improve photodynamic therapy on cells in culture","volume":"57","author":"Gaullier JM","year":"1997","journal-title":"Cancer Res"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1011-1344(98)00206-1"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1993.tb09558.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19881201)62:11<2297::AID-CNCR2820621106>3.0.CO;2-7"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2003.09.002"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2230441"},{"key":"e_1_2_5_13_2","first-page":"575","article-title":"Intracellular iron levels regulate ALA\u2010induced protoporphyrin IX accumulation in activated and malignant lymphocytes","volume":"104","author":"Oseroff AR","year":"1995","journal-title":"implications for selective therapies"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb03412.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.00056.x"},{"key":"e_1_2_5_16_2","first-page":"640","article-title":"Selective distribution of porphyrins in skin thick basal cell carcinoma after topical application of methyl 5\u2010aminolevulinate","volume":"71","author":"Peng Q","year":"2001","journal-title":"J Photochem Photobiol B"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(08)81742-2"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91413-7"},{"key":"e_1_2_5_19_2","first-page":"184","article-title":"Photodynamic therapy with topical 5\u2010aminolevulinic acid for mycosis fungoides","volume":"81","author":"Edstrom DW","year":"2001","journal-title":"clinical and histological response"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2002.01119.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04245.x"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(03)00868-5"},{"key":"e_1_2_5_23_2","first-page":"1367","article-title":"The Sezary syndrome","volume":"17","author":"Vonderheid EC","year":"2003","journal-title":"hematologic criteria"}],"container-title":["Photodermatology, Photoimmunology &amp; 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