{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:19:45Z","timestamp":1780571985927,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T00:00:00Z","timestamp":1162857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Background\/purpose: <\/jats:bold> To study and compare the efficacy of combined 308\u2010nm monochromatic excimer light (MEL) therapy with tacalcitol vs. that of MEL 308\u2010nm therapy alone in treatment of vitiligo.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Thirty\u2010eight patients with vitiligo were enrolled in a single\u2010blind, within patient controlled clinical trial. Symmetrical or nearby lesions were randomly applied with either topical tacalcitol cream or vehicle. Each lesion was treated weekly with the 308\u2010nm MEL, for a total of 12 sessions. Patients were examined at monthly intervals. The mean number of sessions and the cumulative dosage for initial repigmentation were calculated.<\/jats:p><jats:p><jats:bold>Result: <\/jats:bold> Thirty\u2010five patients were evaluated. Treatment with tacalcitol and MEL resulted in higher percentages for excellent repigmentation (25.7%) compared with vehicle and MEL (5.7%) (<jats:italic>P<\/jats:italic>&lt;0.05). Percentages for total response were 71.4% and 60%, respectively (<jats:italic>P<\/jats:italic>&gt;0.05). The mean\u00b1SEM cumulative dose and number of excimer light exposures for initial repigmentation were, respectively, 3.93\u00b10.59\u2003J\/cm<jats:sup>2<\/jats:sup> and 4.52\u00b10.49 at the tacalcitol side, and, respectively, 4.99\u00b10.68\u2003J\/cm<jats:sup>2<\/jats:sup> and 5.3\u00b10.52 at the vehicle side (<jats:italic>P<\/jats:italic>&lt;0.05).<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> Our results have shown that concurrent topical tacalcitol potentiates the efficacy of the 308\u2010nm MEL in the treatment of vitiligo, and that this combination achieves earlier pigmentation with a lower total dosage.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2006.00250.x","type":"journal-article","created":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T13:57:55Z","timestamp":1162907875000},"page":"310-314","source":"Crossref","is-referenced-by-count":42,"title":["Topical tacalcitol and 308\u2010nm monochromatic excimer light: a synergistic combination for the treatment of vitiligo"],"prefix":"10.1111","volume":"22","author":[{"given":"Tang","family":"Lu\u2010yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Wen\u2010wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Lei\u2010hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zhi\u2010zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,7]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"531","article-title":"Monochromatic excimer light 308 nm in the treatment of vitiligo","volume":"17","author":"Leone G","year":"2003","journal-title":"a pilot study"},{"key":"e_1_2_5_3_2","first-page":"727","article-title":"Treatment of vitiligo with the 308\u2010nm excimer laser","volume":"46","author":"Spencer JM","year":"2002","journal-title":"a pilot study"},{"key":"e_1_2_5_4_2","first-page":"152","article-title":"Treatment of vitiligo by 308\u2010nm excimer laser","volume":"35","author":"Ostovar N","year":"2004","journal-title":"an evaluation of variables affecting treatment response"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2004.30302.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.140.9.1065"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.1998.v32.pm9808141"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041360209"},{"key":"e_1_2_5_9_2","first-page":"372","article-title":"Open trial of topical tacalcitol [1 alpha 24(OH) 2D3] and solar irradiation for vitiligo vulgaris","volume":"13","author":"Katayama I","year":"2003","journal-title":"upregulation of c-Kit mRNA by cultured melanocytes"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70021-8"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000017991"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04286.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2001.04381.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2005.00139.x"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2002.00407.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1468-3083.2003.00795.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00456842"},{"key":"e_1_2_5_18_2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF02505036","article-title":"Defective calcium transport in vitiliginous melanocytes","volume":"228","author":"Schallreuter KU","year":"1996","journal-title":"Arch Dermatol Res"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041360209"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12480255"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06321.x"}],"container-title":["Photodermatology, Photoimmunology &amp; 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