{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T01:54:38Z","timestamp":1767664478942},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T00:00:00Z","timestamp":1162857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Photodynamic therapy with topical 5\u2010aminolevulinic acid (ALA), followed by irradiation with red light (ALA\u2010PDT), is used for non\u2010melanoma skin cancer and other dermatological diseases. Pain during and after light exposure is a well\u2010known adverse advent that may be a limiting factor for treatment, particularly, in viral warts.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> To assess the pain induced by ALA\u2010PDT, we asked 45 patients enrolled in a randomized, placebo\u2010controlled trial with six consecutive ALA\u2010 and placebo\u2010PDT treatments for recalcitrant foot and hand warts to fill in questionnaires about pain immediately and 24\u2003h after each treatment.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Immediately and 24\u2003h after each of the six treatments, pain intensity was significantly higher in warts treated with ALA\u2010PDT than in warts treated with placebo\u2010PDT (<jats:italic>P<\/jats:italic>&lt;0.028). Severe or unbearable pain was reported from a median of 17% (6\u201331%) of the ALA \u2010treated warts and from a median of 2% (0\u201315%) from the placebo\u2010treated warts immediately after the treatments. With increasing treatments, no significant change in pain intensity was observed and no significant relation was found between the pain intensity and the relative change in wart area. The pain was primarily characterized as burning and shooting. The pain lasted about 30\u2003h (range: 1\u201396\u2003h).<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> We conclude that pain induced by ALA\u2010PDT is of such intensity in about one\u2010fifth of the warts that pain relief is indicated.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2006.00259.x","type":"journal-article","created":{"date-parts":[[2006,11,7]],"date-time":"2006-11-07T13:57:55Z","timestamp":1162907875000},"page":"304-309","source":"Crossref","is-referenced-by-count":31,"title":["Pain induced by photodynamic therapy of warts"],"prefix":"10.1111","volume":"22","author":[{"given":"I.\u2010M.","family":"Stender","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Molke Borgbjerg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Villumsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Lock\u2010Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.\u2010C.","family":"Wulf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)90013-8"},{"key":"e_1_2_6_3_2","first-page":"143","article-title":"Photodynamic therapy with endogenous protoporphyrin IX","volume":"6","author":"Kennedy JC","year":"1990","journal-title":"basic principles and present clinical experience"},{"key":"e_1_2_6_4_2","first-page":"289","article-title":"Photodynamic therapy (PDT) and photodiagnosis (PD) using endogenous photosensitization induced by 5\u2010aminolevulinic acid (ALA)","volume":"14","author":"Kennedy JC","year":"1996","journal-title":"mechanisms and clinical results"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.1999.00441.x"},{"key":"e_1_2_6_6_2","first-page":"400","article-title":"Photodynamic therapy of recalcitrant warts with 5\u2010aminolevulinic acid","volume":"79","author":"Stender IM","year":"1999","journal-title":"a retrospective analysis"},{"key":"e_1_2_6_7_2","first-page":"112","article-title":"Autofluorescence spectrum of skin","volume":"6","author":"Na R","year":"2000","journal-title":"component bands and body site variation"},{"key":"e_1_2_6_8_2","first-page":"379","article-title":"Methodological problems in the measurement of pain","volume":"1","author":"Ohnhaus EE","year":"1975","journal-title":"a comparison between the verbal rating scale and the visual analogue scale"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(84)90837-6"},{"key":"e_1_2_6_10_2","first-page":"80","article-title":"McGill pain questionnaire translated into Danish","volume":"9","author":"Drewes AM","year":"1993","journal-title":"experimental and clinical findings"},{"key":"e_1_2_6_11_2","first-page":"447","volume-title":"Textbook of pain","author":"Cousins M","year":"1999"},{"key":"e_1_2_6_12_2","first-page":"409","volume-title":"Textbook of pain","author":"Melzack R","year":"1999"},{"key":"e_1_2_6_13_2","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1046\/j.1365-2133.1996.d01-1076.x","article-title":"Comparison of photodynamic therapy with cryotherapy in the treatment of Bowens disease","volume":"135","author":"Morton CA","year":"1996","journal-title":"Br J Dermatol"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04141.x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70114-3"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)03814-D"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.1997.tb00226.x"},{"key":"e_1_2_6_18_2","first-page":"409","volume-title":"Textbook of pain","author":"Wall PD","year":"1999"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(96)03140-5"}],"container-title":["Photodermatology, Photoimmunology &amp; 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