{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T19:51:52Z","timestamp":1767901912655,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T00:00:00Z","timestamp":1169683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Hand eczema is a chronic skin disorder characterized by a poor response to conventional therapies. Although local PUVA has been proven to be effective in the treatment of chronic hand eczema, little is known about the efficacy and safety of local narrowband UVB (TL\u201001) for this condition. The aim of our study was to compare the efficacy and safety of local narrowband UVB phototherapy with paint\u2010PUVA in patients with chronic hand eczema of dry and dyshidrotic types unresponsive to conventional therapies.<\/jats:p><jats:p><jats:bold>Patients\/methods: <\/jats:bold> Fifteen patients (nine men and six women) with chronic hand eczema of dry and dyshidrotic types was included in this prospective, comparative study based on a left to right comparison pattern. The treatments were administered with local narrowband UVB irradiation on one hand and local paint\u2010PUVA using 0.1% 8\u2010methoxypsoralen gel on the other hand three times a week over a 9\u2010week period. The NB\u2010UVB irradiation was administered using a local NB\u2010UVB system equipped with TL\u201001 lamps. The initial dose was 150\u2003mJ\/cm<jats:sup>2<\/jats:sup> for each patient. An increasing percentile dose schedule based on an increase of 20% was used in every session, until a final dose of 2000\u2003mJ\/cm<jats:sup>2<\/jats:sup> was reached. Evaluation of clinical scores was carried out every 3 weeks during the treatment period.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Twelve of the 15 recruited patients completed the study. There was a statistically significant decrease in the mean clinical score at the third, sixth and nineth week in both groups. The difference in clinical response between the two treatment modalities was not statistically significant at the end of the 9\u2010week treatment period. In the narrowband UVB\u2010treated side, the tolerance of all the patients to the treatment was good all patients well\u2010tolerated the treatment with the exception of mild xerosis that responded to topical emollients.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> Local narrowband UVB phototherapy regimen is as effective as paint\u2010PUVA therapy in patients with chronic hand eczema of dry and dyshidrotic types.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2007.00258.x","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T10:58:12Z","timestamp":1169722692000},"page":"10-14","source":"Crossref","is-referenced-by-count":54,"title":["Local narrowband UVB phototherapy vs. local PUVA in the treatment of chronic hand eczema"],"prefix":"10.1111","volume":"23","author":[{"given":"Engin","family":"Sezer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilker","family":"Etikan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1988.tb03489.x"},{"key":"e_1_2_5_3_2","first-page":"357","article-title":"Treatment of psoriasis with a new UVB\u2010lamp","volume":"69","author":"Larko O.","year":"1989","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_4_2","first-page":"812","article-title":"Epidermal langerhans cell depletion after artificial ultraviolet B irradiation of human skin in vivo","volume":"118","author":"Kolgen W","year":"2002","journal-title":"apoptosis versus migration"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-005-0565-9"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jidsp.5640185"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1046-2023(02)00217-7"},{"key":"e_1_2_5_8_2","first-page":"155","article-title":"Narrowband (312\u2010nm) UV\u2010B suppresses interferon gamma and interleukin (IL) 12 and increases IL\u20104 transcripts","volume":"139","author":"Walters IB","year":"2003","journal-title":"differential regulation of cytokines at the single-cell level"},{"key":"e_1_2_5_9_2","first-page":"48","article-title":"Chronic eczematous dermatitis of the hands","volume":"67","author":"Rosen K","year":"1987","journal-title":"a comparison of PUVA and UVB treatment"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06128.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.1999.tb00056.x"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1994.tb01251.x"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050551"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)80326-X"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000017971"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05318.x"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-004-0522-z"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12363652"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12276682"},{"key":"e_1_2_5_20_2","first-page":"2012","article-title":"Narrow\u2010band ultraviolet B and broad\u2010band ultraviolet A phototherapy in adult atopic eczema","volume":"357","author":"Reynolds NJ","year":"2001","journal-title":"a randomised controlled trial"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890480034005"},{"key":"e_1_2_5_22_2","first-page":"99","article-title":"Biological effects of narrow\u2010band (311\u2003nm TL01) UVB irradiation","volume":"38","author":"El\u2010Ghorr AA","year":"1997","journal-title":"a review"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05447.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb03279.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.01842.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"crossref","first-page":"245","DOI":"10.2340\/0001555571245248","article-title":"Effect of a new narrow\u2010band UVB lamp on photocarcinogenesis in mice","volume":"71","author":"Flindt\u2010Hansen H","year":"1991","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12665385"},{"key":"e_1_2_5_28_2","first-page":"755","article-title":"The photocarcinogenic risk of narrowband UVB (TL\u201001) phototherapy","volume":"152","author":"Man I","year":"2005","journal-title":"early follow-up data"}],"container-title":["Photodermatology, Photoimmunology &amp; 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