{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:20:16Z","timestamp":1761708016656},"reference-count":11,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T00:00:00Z","timestamp":1169683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> The purpose of this study was to evaluate and compare the short\u2010 and long\u2010term therapeutic efficacy of psoralen plus UVA (PUVA) vs. UVB\u2010311\u2003nm in the treatment of patients with disseminated lichen planus.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> A computerized data bank search and chart review revealed that data from a total of 28 patients, including 15 patients [11 women, four men; mean age 47 years (range, 16\u201365 years)] treated between 1998 and 2004 with PUVA and 13 patients [10 women, three men; mean age 51 years (range, 19\u201369 years)] treated with UVB\u2010311\u2003nm, were available at our institution for retrospective analysis.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> All 15 patients (100%) treated with oral PUVA had a complete [<jats:italic>n<\/jats:italic>=10 (67%)] or partial [<jats:italic>n=<\/jats:italic>5 (33%)] clinical response, whereas 10 of 13 patients (77%) treated with UVB\u2010311\u2003nm showed complete [<jats:italic>n=<\/jats:italic>4 (31%)] or partial [<jats:italic>n=<\/jats:italic>6 (46%)] clinical response. Statistical analysis revealed that the initial response to PUVA was superior to that of UVB\u2010311\u2003nm (<jats:italic>P<\/jats:italic>=0.0426; Wilcoxon's exact test). There were no statistically significant differences between the PUVA\u2010 and UVB\u2010311\u2003nm\u2010treated patient groups with regard to mean therapy duration (10.5 vs. 8.2 weeks; <jats:italic>P<\/jats:italic>=0.1107; unpaired, two\u2010tailed Student's <jats:italic>t<\/jats:italic> test) or mean number of treatment exposures (25.9 vs. 22.5; <jats:italic>P<\/jats:italic>=0.1775). After a mean follow\u2010up period of 20.5 months (range, 2\u201349 months) and 35.7 months (range, 3\u201360 months), respectively, disease recurrence or deterioration was observed in seven of 15 PUVA\u2010treated patients (47%) and three of 10 UVB\u2010311\u2003nm\u2010treated patients (30%). Kaplan\u2013Meier lifetime table analysis revealed no statistically significant difference between the 2 treatment groups in terms of sustained overall (i.e., partial and complete) clinical response rate (<jats:italic>P=<\/jats:italic>0.8593; log\u2010rank test).<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> Even though oral PUVA produces a better initial clinical response rate, both oral PUVA and UVB\u2010311\u2003nm are effective treatments for lichen planus that produce similar long\u2010term outcomes.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2007.00261.x","type":"journal-article","created":{"date-parts":[[2007,1,25]],"date-time":"2007-01-25T10:58:12Z","timestamp":1169722692000},"page":"15-19","source":"Crossref","is-referenced-by-count":40,"title":["Psoralen plus UVA vs. UVB\u2010311\u2003nm for the treatment of lichen planus"],"prefix":"10.1111","volume":"23","author":[{"given":"Alexandra","family":"Wackernagel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz J.","family":"Legat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelika","family":"Hofer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Quehenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Kerl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,25]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"463","volume-title":"Fitzpatrick's dermatology in general medicine","author":"Daoud MS","year":"2003"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1978.tb01964.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(84)80312-6"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1981.tb02279.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050590"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1995.01690220118028"},{"key":"e_1_2_6_8_2","first-page":"265","article-title":"Long\u2010term efficacy of PUVA treatment in lichen planus","volume":"4","author":"Helander I","year":"1987","journal-title":"comparison of oral and external methoxsalen regimens"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0151-9638(05)79189-4"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0781.2003.00051.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.2002.01499.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1961.01580140005001"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0781.2007.00261.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0781.2007.00261.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:16:18Z","timestamp":1697037378000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0781.2007.00261.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,25]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1600-0781.2007.00261.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0781.2007.00261.x","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,25]]}}}