{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T15:09:02Z","timestamp":1726758542900},"reference-count":5,"publisher":"Wiley","issue":"2-3","license":[{"start":{"date-parts":[[2007,5,22]],"date-time":"2007-05-22T00:00:00Z","timestamp":1179792000000},"content-version":"vor","delay-in-days":51,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Sezary syndrome and mycosis fungoides are forms of cutaneous T\u2010cell lymphoma, and in the early stage of these diseases psoralen plus ultraviolet A (PUVA) is one of the treatments of choice. Photodynamic therapy using 5\u2010aminolevulinic acid (ALA\u2010PDT) is an effective, non\u2010invasive, and safe treatment for most superficial skin cancers. In order to obtain greater efficacy of PUVA, we investigated the synergistic anti\u2010tumor effects of ALA\u2010PDT and PUVA using 8\u2010methoxypsoralen (8\u2010MOP) and a UVA lamp.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> The <jats:italic>in vitro<\/jats:italic> effects of PUVA and ALA\u2010PDT and their combination in HUT\u201078 cell line from human SS were determined by MTT assay.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> In our results, cell proliferation compared with controls was inhibited to 53.2% with UVA alone, 52.3% with 1\u2003\u03bcM 8\u2010MOP, 43.8% with 100\u2003\u03bcM ALA, and 19.2% with combined 8\u2010MOP and ALA.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> Combined use of ALA and PUVA using 8\u2010MOP and UVA lamps, which are widespread in Japan, had a strong anti\u2010tumor effect <jats:italic>in vitro<\/jats:italic>. Combined treatment with ALA\u2010PDT and PUVA using a UVA lamp appears to have a strong treatment effect.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2007.00280.x","type":"journal-article","created":{"date-parts":[[2007,5,23]],"date-time":"2007-05-23T05:28:22Z","timestamp":1179898102000},"page":"95-97","source":"Crossref","is-referenced-by-count":3,"title":["The effect of psoralen plus ultraviolet A <i>in vitro<\/i> in HUT\u201078 enhances by 5\u2010aminolevulinic acid"],"prefix":"10.1111","volume":"23","author":[{"given":"Yoichi","family":"Akita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Yanagishita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoe","family":"Kuhara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiharu","family":"Kawamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morihiro","family":"Kawada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirono","family":"Nakaseko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Tamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinari","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,5,22]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197608)38:2<683::AID-CNCR2820380210>3.0.CO;2-V"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.13.4553-4561.2000"},{"key":"e_1_2_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90209-3"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06053.x"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/120347540100500103"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0781.2007.00280.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0781.2007.00280.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T12:20:10Z","timestamp":1693484410000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0781.2007.00280.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":5,"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1111\/j.1600-0781.2007.00280.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0781.2007.00280.x","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}