{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:26:27Z","timestamp":1778840787297,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,8,30]],"date-time":"2007-08-30T00:00:00Z","timestamp":1188432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Vitamin D3 is produced in the epidermis by ultraviolet (UV) radiation (290\u2013315\u2003nm) of 7\u2010dehydrocholesterol. A similar range of 290\u2013320\u2003nm (broadband UVB) has been successfully used for years to treat psoriasis. The aim of this study was to investigate whether UVB therapy was able to influence vitamin D synthesis in psoriasis patients.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Twenty\u2010four postmenopausal, white Caucasian women, aged 69\u00b15.9 (mean\u00b1SD), with active plaque psoriasis, were treated with broadband UVB two to three times per week for 8\u201312 weeks. The serum concentrations of calcidiol (25(OH)D3), calcitriol (1,25(OH)<jats:sub>2<\/jats:sub>D3), intact parathyroid hormone (PTH), thyroid hormones, osteocalcin, calcium and creatinine were measured before the first and after the last dose of radiation. Bone density was measured using Dual\u2010Energy X\u2010ray Absorptiometry (Hologic Delphi A) at the hip and lumbar spine.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> Serum levels of 25(OH)D3 increased from 36.8\u00b117\u2003ng\/ml (mean\u00b1SD) to 59.6\u00b118.7\u2003ng\/ml (<jats:italic>P<\/jats:italic>&lt;0.001) after the UVB treatment period. Serum PTH decreased from 62.8\u00b125.7\u2003ng\/l to 48.2\u00b117.4\u2003ng\/l (<jats:italic>P<\/jats:italic>&lt;0.001). Secondary hyperparathyroidism (PTH&gt;65\u2003ng\/l) was revealed in seven patients (29%) in whom PTH values were suppressed by the UVB therapy. The serum levels of calcitriol, calcium, osteocalcin, thyroid hormones and creatinine were unaltered.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> UVB therapy in elderly psoriatic women improved psoriasis, increased serum 25(OH)D3 synthesis and reduced serum PTH concentrations.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2007.00301.x","type":"journal-article","created":{"date-parts":[[2007,9,4]],"date-time":"2007-09-04T11:19:07Z","timestamp":1188904747000},"page":"172-178","source":"Crossref","is-referenced-by-count":28,"title":["UVB therapy increases 25(OH) vitamin D syntheses in postmenopausal women with psoriasis"],"prefix":"10.1111","volume":"23","author":[{"given":"Amra","family":"Osmancevic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kerstin","family":"Landin\u2010Wilhelmsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olle","family":"Lark\u00f6","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Mellstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann\u2010Marie","family":"Wennberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Hulth\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne\u2010Lene","family":"Krogstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,30]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"51","article-title":"The cutaneous photosynthesis of previtamin D3","volume":"77","author":"Holick MF.","year":"1981","journal-title":"a unique photoendocrine system"},{"key":"e_1_2_7_3_2","first-page":"224","article-title":"The vitamin D story","volume":"2","author":"DeLuca HF.","year":"1988","journal-title":"a collaborative effort of basic science and clinical medicine"},{"key":"e_1_2_7_4_2","first-page":"331","article-title":"The vitamin D endocrine system","volume":"3","author":"Norman AW","year":"1982","journal-title":"steroid metabolism, hormone receptors, and biological response (calcium binding proteins)"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198904133201506"},{"key":"e_1_2_7_6_2","first-page":"575","article-title":"Studies of vitamin D deficiency in man","volume":"44","author":"Preece MA","year":"1975","journal-title":"Q J Med"},{"issue":"11","key":"e_1_2_7_7_2","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1093\/jn\/120.suppl_11.1464","article-title":"The use and interpretation of assays for vitamin D and its metabolites","volume":"120","author":"Holick MF.","year":"1990","journal-title":"J Nutr"},{"key":"e_1_2_7_8_2","first-page":"373","article-title":"Influence of season and latitude on the cutaneous synthesis of vitamin D3","volume":"67","author":"Webb AR","year":"1988","journal-title":"exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112134"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/58.6.882"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)78933-9"},{"key":"e_1_2_7_12_2","first-page":"94","article-title":"Benefits and requirements of vitamin D for optimal health","volume":"10","author":"Grant WB","year":"2005","journal-title":"a review"},{"key":"e_1_2_7_13_2","first-page":"400","article-title":"Sunlight increases serum 25(OH) vitamin D concentration whereas 1,25(OH)2D3 is unaffected. 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