{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T23:41:32Z","timestamp":1779234092346,"version":"3.51.4"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,8,30]],"date-time":"2007-08-30T00:00:00Z","timestamp":1188432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Photodynamic therapy (PDT) is based on the principle of using light excitation of a wavelength\u2010specific endogenous or exogenous photosensitizer to destroy the target tissue, and has shown efficacy in the treatment of certain non\u2010melanoma skin cancers. PDT using aminolevulinic acid (5\u2010ALA) has attracted attention in the treatment of acne vulgaris.<\/jats:p><jats:p><jats:bold>Method: <\/jats:bold> Twenty patients with moderate to severe acne vulgaris on the face were treated with four sessions of topical ALA\u2010PDT with blue light (415\u2003nm) on the right side of the face compared with blue light alone on the left side of the face, each treatment being 1 week apart. Ten percent of topical ALA was applied to acne spots on the right side of the face with a 1\u2010h incubation period and the entire face was treated with 48\u2003J\/cm<jats:sup>2<\/jats:sup> of 415\u00b15\u2003nm light from an articulated LED planar array. Evaluation was performed by counting acne lesions at baseline, 4, 8, 12 and 16 weeks after the beginning of the treatment. Biophysical measurements included sebum levels and the erythema, and melanin indices.<\/jats:p><jats:p><jats:bold>Result: <\/jats:bold> At the given assessment times 4, 8, 12 and 16 weeks after the beginning of the treatment, the mean percent reduction in inflamed lesions counts tended to be higher in the ALA\u2010PDT areas; it was 32%, 50.9%, 65.9% and 71.1%, respectively, compared with the blue\u2010light\u2010alone treatment, which was 20.7%, 27%, 57.7% and 56.7%, respectively, but without any statistical significance (<jats:italic>P<\/jats:italic>=0.092). There was no demonstrable significant change in sebum excretion, erythema or the melanin index after treatment. The side effects were pain, stinging, peeling, erythema, pruritus, oozing and pustules. These side effects were stronger on the ALA\u2010PDT\u2010treated side.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> From this study, the trend for ALA\u2010PDT with blue light to be superior to blue light alone was observed, but it did not reach statistical significance. ALA\u2010PDT had more side effects.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2007.00303.x","type":"journal-article","created":{"date-parts":[[2007,9,4]],"date-time":"2007-09-04T11:19:07Z","timestamp":1188904747000},"page":"186-190","source":"Crossref","is-referenced-by-count":53,"title":["Efficacy of ALA\u2010PDT vs blue light in the treatment of acne"],"prefix":"10.1111","volume":"23","author":[{"given":"R.","family":"Akaraphanth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Kanjanawanitchkul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Gritiyarangsan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,30]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.133.2.811-815.1978"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1986.tb05592.x"},{"key":"e_1_2_6_4_2","first-page":"601","article-title":"Studies on the mechanism of tumor destruction by photoradiation therapy","volume":"170","author":"Henderson BW","year":"1984","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2000.00046.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2001.04086.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03481.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000246114"},{"issue":"2","key":"e_1_2_6_9_2","first-page":"5","article-title":"Study design and selection criteria in the best study","volume":"71","author":"Rist T","year":"2003","journal-title":"Cutis"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03528.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/09546630500283664"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.12.033"},{"key":"e_1_2_6_13_2","first-page":"969","article-title":"Photodynamic therapy of acne vulgaris using methyl aminolaevulinate","volume":"154","author":"Wiegell SR","year":"2006","journal-title":"a blinded, randomized, controlled trial"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2005.00181.x"},{"key":"e_1_2_6_15_2","first-page":"616","article-title":"Topical aminolaevulinic acid\u2010photodynamic therapy for the treatment of acne vulgaris","volume":"151","author":"Pollock B","year":"2004","journal-title":"a study of clinical efficacy and mechanism of action"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0781.2007.00303.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0781.2007.00303.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T15:10:15Z","timestamp":1697037015000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0781.2007.00303.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,30]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1111\/j.1600-0781.2007.00303.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0781.2007.00303.x","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,30]]}}}