{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:17:09Z","timestamp":1792801029422,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,5,13]],"date-time":"2008-05-13T00:00:00Z","timestamp":1210636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:bold>Background: <\/jats:bold> An extract of the tropical fern <jats:italic>Polypodium leucotomos<\/jats:italic> (PL) administered orally to mice inhibits ultraviolet B (UVB) radiation\u2010induced skin cancer formation. UVB\u2010induced murine skin cancers occur, in part, because of UVB\u2010induced immunosuppression. Thus, we examined whether PL inhibits UVB\u2010suppression of the induction of contact hypersensitivity (CHS) locally or systemically.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> C57BL\/6 mice received standard drinking water or water\u2010containing PL. In the local model, mice were shaved on the dorsum and exposed to 3500\u2003J\/m<jats:sup>2<\/jats:sup> of UVB radiation daily for 4 days. Control mice were not irradiated. After the last irradiation they were sensitized to oxazolone topically at the irradiated site. To examine the ability of PL to inhibit systemic UVB\u2010induced immunosuppression, mice were given 10\u2003000\u2003J\/m<jats:sup>2<\/jats:sup> of UVB radiation once and immunized at a non\u2010exposed site 3 days later. Six days after immunization (in both models), mice were challenged on the ears with oxazolone and 24\/48\u2003h ear swelling assessed.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> PL in drinking water significantly reduced the inhibition of CHS observed with exposure to UVB radiation in both the local and systemic models.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold> The ability of PL to inhibit UVB radiation\u2010induced immune suppression may explain, in part, its ability to inhibit UVR\u2010induced skin cancer induction in mice.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2008.00352.x","type":"journal-article","created":{"date-parts":[[2008,5,13]],"date-time":"2008-05-13T09:24:24Z","timestamp":1210670664000},"page":"134-141","source":"Crossref","is-referenced-by-count":27,"title":["Polypodium leucotomos inhibits ultraviolet B radiation\u2010induced immunosuppression"],"prefix":"10.1111","volume":"24","author":[{"given":"Jonathan 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