{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:39:58Z","timestamp":1762954798339},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,9,11]],"date-time":"2008-09-11T00:00:00Z","timestamp":1221091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2008,10]]},"abstract":"<jats:p>The mechanisms whereby narrowband ultraviolet B (UVB) (311\u2013313\u2003nm, TL01) phototherapy are effective in psoriasis may differ from those occurring in broadband UVB phototherapy. In the present study, changes in epidermal cells as a result of TL01 therapy were assessed in the skin of patients with psoriasis. The non\u2010lesional skin of five subjects with plaque psoriasis was biopsied before and after a series of 12 whole\u2010body TL01 treatments. Following appropriate staining of skin sections, the numbers of p53\u2010positive keratinocytes, sunburn cells and Langerhans cells in the epidermis were counted. TL01 therapy induced a threefold increase in the number of p53\u2010positive epidermal cells, a 12\u2010fold increase in sunburn cells and a twofold decrease in Langerhans cells. The increase in epidermal p53 expression and apoptosis of keratinocytes together with the depletion of Langerhans cells in the non\u2010lesional skin of psoriasis patients are likely to contribute to the effectiveness of TL01 phototherapy.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2008.00366.x","type":"journal-article","created":{"date-parts":[[2008,9,11]],"date-time":"2008-09-11T11:57:40Z","timestamp":1221134260000},"page":"268-269","source":"Crossref","is-referenced-by-count":23,"title":["Local effects of TL01 phototherapy in psoriasis"],"prefix":"10.1111","volume":"24","author":[{"given":"Bernadette","family":"DeSilva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roddie C.","family":"McKenzie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A. A.","family":"Hunter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Norval","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,9,11]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"155","article-title":"Narrowband (312\u2010nm) UV\u2010B suppresses interferon gamma and interleukin (IL) 12 and increases IL\u20104 transcripts","volume":"139","author":"Walters IB","year":"2003","journal-title":"differential regulation of cytokines at the single-cell level"},{"key":"e_1_2_5_3_2","first-page":"99","article-title":"Biological effects of narrow\u2010band (311\u2003nm TL01) UVB irradiation","volume":"38","author":"El\u2010Ghorr AA","year":"1997","journal-title":"a review"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.1997.tb00125.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2006.00197.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2001.00765.x"},{"key":"e_1_2_5_7_2","first-page":"365","article-title":"The sunburn cell revisited","volume":"1","author":"Sheehan JM","year":"2002","journal-title":"an update on mechanistic aspects"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0906-6705.2003.00057.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700856"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0781.2008.00366.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0781.2008.00366.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T21:56:43Z","timestamp":1697061403000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0781.2008.00366.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,11]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["10.1111\/j.1600-0781.2008.00366.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0781.2008.00366.x","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,11]]}}}