{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:06:01Z","timestamp":1789909561700,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2011,7,5]],"date-time":"2011-07-05T00:00:00Z","timestamp":1309824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:p><jats:bold>Background: <\/jats:bold> Cryotherapy cannot destroy subclinical human papillomavirus\u2010infected cells of condylomata acuminata (CA). The topical application of aminolevulinic acid (ALA) results in a shallow penetration depth in CA lesions (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#b1\">1<\/jats:ext-link>).<\/jats:p><jats:p><jats:bold>Objectives: <\/jats:bold> To compare the efficacy and safety of cryotherapy plus ALA\u2010photodynamic therapy (PDT) with cryotherapy in the treatment of multiple CA.<\/jats:p><jats:p><jats:bold>Methods: <\/jats:bold> Eighty patients with multiple CA received cryotherapy plus ALA\u2010PDT (<jats:italic>n<\/jats:italic>=40) or cryotherapy plus placebo\u2010PDT (<jats:italic>n<\/jats:italic>=40). After cryotherapy, a 20% ALA or a placebo solution was applied to the CA area 3\u2003h before illumination with red light (635\u2003nm, 100\u2003mW\/cm<jats:sup>2<\/jats:sup>, 100\u2003J\/cm<jats:sup>2<\/jats:sup>). The treatment was repeated 7 days after the first treatment if the lesions were not completely resolved. The complete response rate, recurrence rate and adverse effects in the two groups were analyzed.<\/jats:p><jats:p><jats:bold>Results: <\/jats:bold> After two treatments, the complete response rates in the combined group (cryotherapy plus ALA\u2010PDT) and cryotherapy group were 32.4% (36\/111) and 32.6% (43\/132) in the anal area (<jats:italic>P<\/jats:italic>&gt;0.05), 100% (32\/32) and 54.5% (18\/33) in the urethral meatus (<jats:italic>P<\/jats:italic>&lt;0.05), and 94.2% (129\/137) and 50.5% (56\/111) in the external genitals (<jats:italic>P<\/jats:italic>&lt;0.05), respectively. The recurrence rates in the combined group and cryotherapy group were 24.3% (27\/111) and 31.1% (41\/132) in the anal area (<jats:italic>P<\/jats:italic>&gt;0.05), 9.4% (3\/32) and 39.4% (13\/33) in the urethral meatus (<jats:italic>P<\/jats:italic>&lt;0.05), and 3.6% (5\/137) and 31.5% (35\/111) in the external genitals (<jats:italic>P<\/jats:italic>&lt;0.05), respectively. The adverse effects in each group included mild to moderate pain, edema, erosion and hypopigmentation, without any infection, ulcers, scarring or urethral malformations.<\/jats:p><jats:p><jats:bold>Conclusion: <\/jats:bold> Cryotherapy plus ALA\u2010PDT is a more effective regimen for the treatment of multiple CA compared with cryotherapy alone.<\/jats:p>","DOI":"10.1111\/j.1600-0781.2011.00592.x","type":"journal-article","created":{"date-parts":[[2011,7,6]],"date-time":"2011-07-06T01:35:01Z","timestamp":1309916101000},"page":"176-180","source":"Crossref","is-referenced-by-count":43,"title":["A randomized clinical comparative study of cryotherapy plus photodynamic therapy vs. cryotherapy in the treatment of multiple condylomata acuminata"],"prefix":"10.1111","volume":"27","author":[{"given":"Xia","family":"Mi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wangxing","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heyi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya\u2010Gang","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,7,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-697-9_7"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/656368"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jncimonographs.a003473"},{"key":"e_1_2_6_5_2","first-page":"S2","article-title":"Traditional therapies for the treatment of condylomata acuminata (genital warts)","volume":"39","author":"Jablonska S.","year":"1998","journal-title":"Australas J Dermatol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2008.11.004"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(85)90359-0"},{"key":"e_1_2_6_8_2","first-page":"1245","article-title":"Guidelines for topical photodynamic therapy","volume":"159","author":"Morton CA","year":"2008","journal-title":"update"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07648.x"},{"key":"e_1_2_6_10_2","first-page":"736","article-title":"Selectivity of protoporphyrin IX fluorescence for condylomata after topical application of 5\u2010aminolevulinic acid","volume":"137","author":"Ross EV","year":"1997","journal-title":"implications for photodynamic treatment"},{"key":"e_1_2_6_11_2","first-page":"806","article-title":"Penetration enhancement of two topical 5\u2010aminolaevulinic acid formulations for photodynamic therapy by erbium","volume":"19","author":"Forster B","year":"2010","journal-title":"YAG laser ablation of the stratum corneum: continuous versus fractional ablation"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1258\/0956462053420130"},{"key":"e_1_2_6_13_2","first-page":"5","article-title":"An evidence\u2010based review of medical and surgical treatments of genital warts","volume":"12","author":"Scheinfeld N.","year":"2006","journal-title":"Dermatol Online J"},{"key":"e_1_2_6_14_2","first-page":"9","article-title":"Nathaniel Bouganim. 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