{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T08:14:31Z","timestamp":1780992871110,"version":"3.54.1"},"reference-count":10,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T00:00:00Z","timestamp":1325030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2012,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Imatinib mesylate (<jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>) is a phenylaminopyrimidine that represents the first\u2010line treatment for chronic myeloid leukemia (<jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>), Philadelphia chromosome\u2010positive. It acts as a potent and selective inhibitor of the bcr\u2010abl fusion protein by a competitive inhibition at the adenosine triphosphate\u2010binding site of the enzyme, which leads to the inhibition of tyrosine phosphorylation of the proteins involved in bcr\u2010abl signal transduction. <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> is generally well tolerated and usually provokes only mild side effects consisting of nausea, myalgia, edema and muscle cramps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Observation<\/jats:title><jats:p>This is a report of a patient affected by <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content>, who developed a photoinduced dermatitis and an oral lichenoid reaction associated with <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> treatment. The lesions were resolved, thanks to the withdrawal of the therapy, and they relapsed after the reintroduction of <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content>, confirming the drug\u2010induced pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Skin changes are the most common non\u2010hematologic side effects to <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> treatment and are usually dose dependent. In particular, patients with <jats:styled-content style=\"fixed-case\">IM<\/jats:styled-content> therapy reported a lightening and depigmentation of the skin, that may alter the skin protection against ultraviolet exposure, with a possible subsequent intolerance to sun exposure, as reported in our patient, and higher risk of skin cancer. They are frequently self\u2010limited or easily managed; nevertheless, in some cases, the therapy needs to be discontinued or may only be continued with concomitant oral steroid.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0781.2011.00621.x","type":"journal-article","created":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T01:07:06Z","timestamp":1325120826000},"page":"2-5","source":"Crossref","is-referenced-by-count":22,"title":["Photoinduced dermatitis and oral lichenoid reaction in a chronic myeloid leukemia patient treated with imatinib mesylate"],"prefix":"10.1111","volume":"28","author":[{"given":"Valeria","family":"Brazzelli","sequence":"first","affiliation":[{"name":"Institute of Dermatology University of Pavia and Foundation IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Muzio","sequence":"additional","affiliation":[{"name":"Institute of Dermatology University of Pavia and Foundation IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giambattista","family":"Manna","sequence":"additional","affiliation":[{"name":"Institute of Dermatology University of Pavia and Foundation IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Moggio","sequence":"additional","affiliation":[{"name":"Institute of Dermatology University of Pavia and Foundation IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Vassallo","sequence":"additional","affiliation":[{"name":"Institute of Dermatology University of Pavia and Foundation IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester","family":"Orlandi","sequence":"additional","affiliation":[{"name":"Institute of Hematology University of Pavia and Foundation IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Fiandrino","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pavia and Foundation IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Lucioni","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Pavia and Foundation IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Borroni","sequence":"additional","affiliation":[{"name":"Institute of Dermatology University of Pavia and Foundation IRCCS Policlinico S. Matteo  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,28]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01981.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.44"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe030009"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441401"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.10.888"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07359.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2006.00208.x"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.22.428"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000063899"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630410015556"}],"container-title":["Photodermatology, Photoimmunology &amp; Photomedicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0781.2011.00621.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0781.2011.00621.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T10:50:27Z","timestamp":1700563827000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0781.2011.00621.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12,28]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["10.1111\/j.1600-0781.2011.00621.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0781.2011.00621.x","archive":["Portico"],"relation":{},"ISSN":["0905-4383","1600-0781"],"issn-type":[{"value":"0905-4383","type":"print"},{"value":"1600-0781","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12,28]]}}}