{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T08:59:23Z","timestamp":1717923563074},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2011,12,28]],"date-time":"2011-12-28T00:00:00Z","timestamp":1325030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Photoderm Photoimm Photomed"],"published-print":{"date-parts":[[2012,2]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Squamous cell carcinoma (SCC<\/jats:styled-content>) is linked with the lifelong cumulative effect of ultraviolet radiation (UVR<\/jats:styled-content>). In contrast, epidemiological data have shown that sunburn in childhood is a stronger risk factor for cutaneous malignant melanoma than continuous UVR<\/jats:styled-content>, indicating a higher carcinogenic sensitivity early in life.<\/jats:p><\/jats:sec>Methods<\/jats:title>We investigated how a high neonatal dose of UVR<\/jats:styled-content> affects the development of SCC<\/jats:styled-content> in mice irradiated later in life. We used simulated solar radiation (sun) and solarium radiation (solarium). Ninety\u2010nine C3.Cg\/TifBomTac<\/jats:styled-content>\u2010immunocompetent hairless mice received 0, 25 or 35 standard erythema doses (SED<\/jats:styled-content>) UVR<\/jats:styled-content> when they were 4 days old followed by 4 SED<\/jats:styled-content> sun or 4 SED<\/jats:styled-content> solarium three times\/weekly from 9 weeks of age.<\/jats:p><\/jats:sec>Results<\/jats:title>Tumours developed faster in mice treated with 35 SED UVR<\/jats:styled-content>\u2009+\u20094 SED<\/jats:styled-content> sun compared with 4 SED<\/jats:styled-content> sun, but no change was observed in the cumulative dose required to achieve tumours. Tumours also developed faster in mice treated with 35 SED UVR<\/jats:styled-content>\u2009+\u20094 SED<\/jats:styled-content> solarium compared with 4 SED<\/jats:styled-content> solarium, and a difference was also observed in the cumulative dose required to achieve tumours. If the S<\/jats:styled-content>kin C<\/jats:styled-content>ancer U<\/jats:styled-content>trecht\u2010P<\/jats:styled-content>hiladelphia\u2010murine spectrum was used to weigh the delivered irradiance instead of the International Commission on Illumination erythema action spectrum, tumours developed after the same accumulated dose.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>In conclusion, this study does not indicate increased sensitivity to induction of SCC<\/jats:styled-content> early in life.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0781.2011.00629.x","type":"journal-article","created":{"date-parts":[[2011,12,29]],"date-time":"2011-12-29T01:07:06Z","timestamp":1325120826000},"page":"26-33","source":"Crossref","is-referenced-by-count":3,"title":["Neonatal mice do not have increased sensitivity to induction of squamous cell carcinomas"],"prefix":"10.1111","volume":"28","author":[{"given":"Catharina M.","family":"Lerche","sequence":"first","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital Bispebjerg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital of South Jutland Soenderborg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans Christian","family":"Wulf","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital Bispebjerg Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,12,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00756.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60638-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008980919928"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/35095108"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2006.02.024"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-77574-6_13"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-05-2476"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00812.x"},{"key":"e_1_2_6_10_1","first-page":"242","article-title":"Aspects of exposure to UVA tanning sources. 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